Congenital hemorrhagic diathesis of the prothrombin complex

Stuart Clotting Defect. II. Genetic Aspects of a `New' Hemorrhagic State

“…We showed that, in contrast to certain other cases in the literature (5)(6)(7)(8), the defect in our patient's plasma could not be corrected by Russell viper venom, and that his serum was inactive in the thromboplastin generation test. In this last respect our patient's defect resembled that of some of the previously reported cases (8)(9)(10)(11) but differed from certain others (5,6,(12)(13)(14).…”

Stuart Clotting Defect. I. Segregation of an Hereditary Hemorrhagic State from the Heterogeneous Group Heretofore Called “Stable Factor” (SPCA, Proconvertin, Factor VII) Deficiency

“…Although the three terms have been used synonymously since that time, the literature shows no evidence that the identity has been rigorously established. Since the case of Alexander, Goldstein, Landwehr, and Cook (1), 29 other cases (Table I) of a congenital deficiency of these presumably identical factors have been described (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). Our present studies indicate that the patient of Crockett, Shotton, Craddock, and Leavell (25) also belongs in the same group.…”

Familial Multiple Coagulation Factor Deficiencies

“…Three cases have been reported in whom deficiencies of the vitamin K-dependent fac tors are well documented (Table 10, ref. 63,87,95). An additional report described a possible case of FMFD III, but documentation was incomplete [32].…”

“…The first reported case of FMFD III, R.G. (Proband 1), was a woman with a lifelong hemorrhagic tendency beginning in the mid-1920s [95]. Dicumarol, the first available vitamin K antagonist, was discovered in 1939 by Link and his co-workers [134] and there fore was unavailable during the early years of her life.…”