Congenital hemangiomas and infantile hemangioma: missing links

Mulliken, John B.; Enjolras, O

doi:10.1016/j.jaad.2003.10.670

Cited by 307 publications

(238 citation statements)

References 31 publications

Supporting

Mentioning

205

Contrasting

Unclassified

Order By: Relevance

“…Multifocal and diffuse HH correspond with IH, the most common vascular tumor in children that shows a rapid postnatal growth (0-12 mo) followed by slow involution (1-5 years). It is probable that most HH remain undiagnosed since they are asymptomatic self-limiting lesions, although they often come to clinical attention while screening for visceral hemangioma based on the presence of multiple cutaneous IH (Figure 1), since the liver is the most commonly involved organ [3,7,8] . Some patients may develop a congestive heart failure associated with highvolume vascular shunting and treatment is warranted.…”

Section: Hepatic Hemangiomamentioning

confidence: 99%

Differential diagnosis and management of liver tumors in infants

Fernández-Pineda

Cabello-Laureano

2014

WJH

View full text Add to dashboard Cite

During the first year of life, most of the liver neoplasms are benign in origin, but some of these histologically benign lesions may be challenging in their management. Although most hepatic hemangiomas can be safely observed until involution is documented, some patients will need treatment due to progressive hepatomegaly, hypothyroidism and/or cardiac failure. Large mesenchymal hamartomas may require extensive hepatic resection and an appropriate surgical plan is critical to obtain good results. For malignant neoplasms such as hepatoblastoma, complete surgical resection is the mainstay of curative therapy. The decision about whether to perform an upfront or delayed resection of a primary liver malignant tumor is based on many considerations, including the ease of resection, surgical expertise, tumor histology and stage, and the likely chemosensitivity of the tumor. This article reviews the initial management of the more common hepatic tumors of infancy, focusing on the differential diagnosis and treatment options.

show abstract

Section: Hepatic Hemangiomamentioning

confidence: 99%

Differential diagnosis and management of liver tumors in infants

Fernández-Pineda

Cabello-Laureano

2014

WJH

View full text Add to dashboard Cite

show abstract

“…2 De manera ocasional, pueden tener una involución significativa, aunque no total, durante el primer año y dejar una lesión residual similar a un NICH, 6 fenómeno que algunos autores han denominado "RICH a NICH" 5 ( Figura 3). Incluso se sugiere que los RICH y los NICH podrían formar parte de un espectro.…”

Section: Discussionunclassified

“…8 Se localizan con mayor frecuencia en la cabeza, el cuello 5 y en las extremidades superiores, cerca de las articulaciones. 6 Su frecuencia es igual para ambos sexos, 6 hecho que se contrapone a lo que ocurre con los hemangiomas de la infancia, que son 3-5 veces más frecuentes en niñas, 2 y con los NICH, que predominan en varones (3:2). 1 Si bien la mayoría de los pacientes evoluciona de manera favorable, se han descrito complicaciones graves relacionadas con los RICH: ulceración y sangrado, 9 insuficiencia cardíaca 5 y trombocitopenia con coagulopatía por consumo 10 (fenómeno distinto del síndrome de KasabachTabla 2.…”

Section: Discussionunclassified

“…2 La técnica de inmunohistoquímica para la detección de GLUT-1 (proteína transportadora de glucosa-1) permite diferenciarlos de los HI, ya que se expresa en el endotelio de los HI y no en los HC. 1,2,6 Debido a que son tumores completamente desarrollados antes del nacimiento, el diagnóstico prenatal es factible por ecografía obstétrica, sobre todo si la lesión se localiza en la cabeza y el cuello. En dos de nuestros pacientes, pudo observarse por ecografía una tumoración en la cabeza durante el tercer trimestre de gestación.…”

Section: Richunclassified

See 1 more Smart Citation

Hemangiomas congénitos rápidamente involutivos. Serie de 25 casos

et al. 2014

View full text Add to dashboard Cite

Arch Argent Pediatr 2014;112(2):e61-e65 / e61Presentación de casos clínicos RESUMEN Los hemangiomas congénitos rápidamente involutivos son tumores vasculares muy poco frecuentes, que se caracterizan por estar completamente desarrollados al nacer (congénitos) y por tener una involución espontánea en un corto período (rápidamente involutivos). Describimos una serie de 25 casos de hemangiomas congénitos rápidamente involutivos, de los cuales 12 eran del sexo masculino y 13, femenino. Todos los pacientes eran nacidos a término, con peso adecuado para la edad gestacional. En 17, las lesiones fueron de pequeño tamaño y, en 8, de gran tamaño. Ningún paciente requirió tratamiento. En todos ellos, las lesiones mostraron una rápida involución inicial. Palabras clave: hemangiomas congénitos, hemangiomas congénitos rápidamente involutivos, hemangiomas infantiles, hemangiomas congénitos no involutivos. SUMMARYRapidly involuting congenital hemangiomas are very rare vascular tumours, that are characterized for being completely developed at birth and for involuting in a short period of time after birth. We describe a case series of 25 patients with rapidly involuting congenital hemangiomas. Twelve patients were male and 13 female; they were all born at term. Lesions were small in 17 cases and big in 8. No patient needed active intervention and all lesions showed a rapid initial involution.

show abstract

“…Some investigators have advocated watchful waiting in those cases of type 1 IH without hematologic or hemodynamic abnormalities because these tumors have the potential for spontaneous regression, such as hemangiomas in infants presenting elsewhere in the body. Based on several studies, it would appear that many of these hepatic tumors are examples of the so-called rapidly involuting congenital hemangioma with the characteristic immunohistochemical expression of glucose transporter-1 protein (GLUT-1) by the endothelial cells [16][17][18][19]. The GLUT-1-negative tumors are thought to represent arteriovenous malformations with a proliferating capillary component.…”

Section: Editorialmentioning

confidence: 99%

The Challenges of Vasoformative Tumors of the Liver in Children

Dehner

2004

Pediatr Dev Pathol

View full text Add to dashboard Cite

Congenital hemangiomas and infantile hemangioma: missing links

Cited by 307 publications

References 31 publications

Differential diagnosis and management of liver tumors in infants

Differential diagnosis and management of liver tumors in infants

Hemangiomas congénitos rápidamente involutivos. Serie de 25 casos

The Challenges of Vasoformative Tumors of the Liver in Children

Contact Info

Product

Resources

About