Congenital heart disease:  When to act and what to do?

Samarasinghe, Duminda

doi:10.4038/sljch.v39i2.1952

Cited by 1 publication

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Certain congenital cardiac defects or pulmonary diseases cause severe arterial desaturation and chronic hypoxia, are visible as cyanosis [1,2]. Those cyanotic pediatric patients should undergo critical corrective surgical procedures, which return them back to the normal blood circulation and oxygenation [3,4]. Generally, the chronic hypoxia leads to clinical deterioration of cyanotic pediatric patients post-open heart surgery, where ischemic organs symptoms appear pre and even during ICU (Intensive Care Unit) period post total correction [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

The impact of partial blood replacement on postoperative outcome for pediatric patients with cyanotic heart disease

Saleh¹

2020

J Cardiovasc Med Cardiol

View full text Add to dashboard Cite

Background: Pediatric patients with cyanotic congenital heart disease who underwent open heart corrective surgery, were unfortianetly suffering from postoperative clinical deterioration which may leads to morbidity and mortality. Most of blood transfusion indications are now well managed exclusively with blood component therapy, however concerns about logistics, safety, and relative effi cacy making the blood transfusion a debating procedure in many cardiac centers around the world. The research aimed to investigate the partial blood replacement process for cyanotic pediatric patients by healthy RBCs (red blood cells), solving their postoperative clinical deterioration and proving that the RBCs membrane biomechanical characteristics alterations is the main cause of the adverse effects of prolonged hypoxia on the normal physiological functions of RBCs in oxygen transport and body tissue's perfusion. Methods: 450 Pediatric patients with congenital heart disease were divided into three equal groups, group I acyanotic pediatric patients, group II cyanotic pediatric patients and group III cyanotic pediatric patients treated with the partial blood replacement process. Blood components biophysical characteristics and cardiovascular performance were investigated and the postoperative clinical course was estimated. Results: The results showed the improvement of group III pediatrics, as there were insignifi cant decrease in blood components characteristics, cardiovascular performance and postoperative clinical course estimation compared to group I. Conclusion: The partial blood replacement process after cardiopulmonary bypass procedure for pediatric patients with cyanotic congenital heart disease who undergo corrective congenital surgery, may help in improving their postoperative clinical course and outcomes.

show abstract