Congenital Heart Disease in Twins

Congenital heart disease in a population of dizygotic twins: an echocardiographic study

“…CHD in both dizygotic twins of the same pair was significantly higher than in non-twin siblings of patients with CHD considering only the sibling nearest in age (13.6% vs. 3.8%; pb0.0001) and then all siblings (13.6% vs. 4%; pb0.0001). The recurrence of CHD in dizygotic twins was higher than in previous reports [20,21], probably because of the extensive use of echocardiography in our series.…”

“…Several case reports have been published on CHD in dizygotic twins [16][17][18][19]; most of them include patients with chromosome aberration and no echocardiographic data. Limited data is available on CHD in a large group of dizygotic twins [20,21].…”

Congenital Cardiovascular Malformations in Twins and Triplets From a Population-Based Study

“…Looping defects occurred in 4 monozygotic twin pairs compared with only 1 dizygotic twin pair. The twinning process itself may be implicated in the development of congenital cardiovascular malformations in some of these infants, especially those with looping defects, but concordance of types of defects in 4 When multiple members of a twin or triplet set have CCVM, only the firstborn infant is considered a "case." Zygosity is deter¬ mined chiefly by the mothers' reports, since information regarding placentation or serological markers is usually unavailable.…”

Congenital cardiac abnormalities in monozygotic twins. Report and review of the literature.

“…Several previous studies have noted the surprising lack of concordance for congenital heart malformations in monozygotic twins (Uchida and Rowe, 1957;Nora et al, 1967;Anderson, 1976). The purpose of this communication is to report a unique pair of monozygotic twins in whom secundum atrial septal defect, aneurysm of the membraneous ventricular septum, and frontal plane electrocardiographic left axis deviation were identified in each patient.…”