Congenital heart disease in men – birth characteristics and reproduction: a national cohort study

Kernell, Kristina; Sydsjö, Gunilla; Bladh, Marie; Nielsen, Niels Erik; Josefsson, Ann

doi:10.1186/1471-2393-14-187

Cited by 5 publications

(4 citation statements)

References 14 publications

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“…The register is subject to annual quality control audits. The Swedish Medical Birth Register was complemented by linked data from Statistics Sweden to provide the individual level social data . A quality analysis of the register has been previously described and it is considered to be of high quality …”

Section: Methodsmentioning

confidence: 99%

Geographical differences in preterm delivery rates in Sweden: A population‐based cohort study

Murray

Juodakis

Bacelis

et al. 2018

Acta Obstet Gynecol Scand

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After adjusting for known risk factors, large geographical differences in rates of preterm delivery remain. Additional analyses to look at the effect of environmental and socioeconomic factors on gestational age found an increased gestational age in urban areas. Future research strategies could focus on investigating the urbanity effect to try to explain preterm delivery variation across countries with a very high human development index.

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Section: Methodsmentioning

confidence: 99%

Geographical differences in preterm delivery rates in Sweden: A population‐based cohort study

Murray

Juodakis

Bacelis

et al. 2018

Acta Obstet Gynecol Scand

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“… 1 Infants born small (birth weight <10th percentile) or large (birth weight ≥90th percentile) for sex and gestational age are at increased risk of future health complications, including asthma, 2 obesity 3 and cardiovascular disease. 4 High-income countries generally have similar proportions of babies who weigh <2500 g at birth, but there is greater variation (up to 10%) in the proportion of infants born >4000 g. 5–7 However, such population figures often mask important differences in the distribution of birth weight between ethnic groups. In the USA, white Europeans have more high birth weight (9.6%) than low birth weight infants (7.0%); African–Americans have more low birth weight (13.1%) than high birth weight infants (4.3%); and Hispanics have an equal proportion (7.1% high birth weight and 7.1% low birth weight infants).…”

Section: Introductionmentioning

confidence: 99%

Does the impact of a plant-based diet during pregnancy on birth weight differ by ethnicity? A dietary pattern analysis from a prospective Canadian birth cohort alliance

et al. 2017

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ObjectiveBirth weight is an indicator of newborn health and a strong predictor of health outcomes in later life. Significant variation in diet during pregnancy between ethnic groups in high-income countries provides an ideal opportunity to investigate the influence of maternal diet on birth weight.SettingFour multiethnic birth cohorts based in Canada (the NutriGen Alliance).Participants3997 full-term mother–infant pairs of diverse ethnic groups who had principal component analysis-derived diet pattern scores—plant-based, Western and health-conscious—and birth weight data.ResultsNo associations were identified between the Western and health-conscious diet patterns and birth weight; however, the plant-based dietary pattern was inversely associated with birth weight (β=−67.6 g per 1-unit increase; P<0.001), and an interaction with non-white ethnicity and birth weight was observed. Ethnically stratified analyses demonstrated that among white Europeans, maternal consumption of a plant-based diet associated with lower birth weight (β=−65.9 g per 1-unit increase; P<0.001), increased risk of small-for-gestational age (SGA; OR=1.46; 95% CI 1.08 to 1.54;P=0.005) and reduced risk of large-for-gestational age (LGA; OR=0.71; 95% CI 0.53 to 0.95;P=0.02). Among South Asians, maternal consumption of a plant-based diet associated with a higher birth weight (β=+40.5 g per 1-unit increase; P=0.01), partially explained by cooked vegetable consumption.ConclusionsMaternal consumption of a plant-based diet during pregnancy is associated with birth weight. Among white Europeans, a plant-based diet is associated with lower birth weight, reduced odds of an infant born LGA and increased odds of SGA, whereas among South Asians living in Canada, a plant-based diet is associated with increased birth weight.

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“…We studied CHD overall and subdivided it into simple, moderate, and complex CHD inspired by the guidelines from the European Society of Cardiology 8 (Table S1 ). Individuals who underwent correction of their heart defect were identified in the DNPR using ICD‐8 30 , 31 , 32 , 33 and ICD‐10 procedure codes related to surgical and catheter‐based repair.…”

Section: Methodsmentioning

confidence: 99%

“…Although factors other than fertility influence family size today, lower birth rates in men and women with CHD, in comparison with reference populations, may also point toward impaired fertility. 2 , 30 , 31 , 32 , 33 , 34 …”

mentioning

confidence: 99%

Congenital Heart Disease and Fertility: A Danish Nationwide Cohort Study Including Both Men and Women

Udholm

Arendt

Knudsen

et al. 2023

JAHA

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Background Despite an increasing number of patients with congenital heart disease (CHD) reaching reproductive age, the fertility of these patients remains undescribed. Therefore, the aim of the study was to evaluate the fertility in men and women with CHD by estimating the risk of infertility and comparing the birth rates, proportions of individuals becoming parents or remaining childless, and the number of children per parent with unaffected individuals. Methods and Results The study population consisted of individuals born between 1977 and 2000. Information on CHD, infertility, and live born children were obtained from the Danish health registries. Hazard ratios for infertility were analyzed using a Cox regression model. Differences of proportions and birth rates were calculated and compared between groups. Among 1 385 895 individuals, a total of 8679 (0.6%) were diagnosed with CHD. Men and women with simple or moderate CHD had no increased risk of infertility when compared with the reference population. Estimates for complex CHD groups were too imprecise for evaluation. Individuals with CHD were more often childless with consequently lower birth rates compared with unaffected individuals. However, those becoming parents had the same number of children as the reference population. Conclusions Men and women with simple or moderate CHD had the same risk of infertility as the reference population. Despite patients with CHD more often being childless, those becoming parents had the same number of children as parents without CHD. The current findings increase the knowledge regarding fertility in the CHD population.

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Congenital heart disease in men – birth characteristics and reproduction: a national cohort study

Cited by 5 publications

References 14 publications

Geographical differences in preterm delivery rates in Sweden: A population‐based cohort study

Geographical differences in preterm delivery rates in Sweden: A population‐based cohort study

Does the impact of a plant-based diet during pregnancy on birth weight differ by ethnicity? A dietary pattern analysis from a prospective Canadian birth cohort alliance

Congenital Heart Disease and Fertility: A Danish Nationwide Cohort Study Including Both Men and Women

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