Congenital heart disease in children with Downs syndrome: Turkish experience of 13 years

Nişli, Kemal; Öner, Naci; Candan, Şükrü; Kayserili, Hülya; Tansel, Turkan; Tirelı, Emin; Karaman, Birsen; Eker, Rukiye; Dindar, Aygün; Aydoğan, Ümrah; Başaran, Seher; Ertuğrul, Türkân

doi:10.2143/ac.63.5.2033225

Cited by 36 publications

(42 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cardiol., 8 (1): 20-26, 2015 No ) found that approximately 50% of Down syndrome children in Libya had CHD which is near to Malayza (Azman et al, 2007). On the other hand, the frequency of CHD in Down syndrome observed in this study is less than that reported in Oman (60%) (Venugopalan and Agarwal, 2003), Turkey (78%) (Nisli et al, 2008) and Guatimala (80%) (Vida et al, 2005). In comparison to local studies done in Saudi Arabia, Al-Jarallah (2009) reported that CHD was diagnosed in 49% of Down syndrome children in Riyadh region, the capital of Saudi Arabia.…”

Section: Discussioncontrasting

confidence: 70%

Congenital Heart Diseases in Saudi Down Syndrome Children: Frequency and Patterns in Almadinah Region

El-Attar¹

2014

Research J. of Cardiology

View full text Add to dashboard Cite

Congenital Heart Diseases (CHDs) occur in about 40-50% of neonates born with Down syndrome. Increased incidence of CHDs in children with Down syndrome in certain populations has been associated with widespread consanguinity. Up till now there is no explanation for why some Down syndrome patients are susceptible to CHDs. This study aims to evaluate the frequency and patterns of CHDs in Down syndrome children at Almadina province in the west of Saudi Arabia and compare it with other previously reported studies. The study included Down syndrome children referred to the pediatric cardiology clinic for screening of CHDs. Full history taking, pedigree analysis and clinical examination were done to all cases. Parental consanguinity was documented and echocardiography was done to assess the cardiac lesions. Out of 110 Down syndrome children, 45 (40.9%) had CHDs were selected. Parental consanguinity was present in 26/45 (57.8%). The most frequent lesion was AVSD (33.3%), followed by VSD (22.2%), then ASD (13.3%), PDA was present in 8.8% and TOF was diagnosed in one case. The most common combination of cardiac lesions in Down syndrome cases included in this study was ASD with VSD. Conclusion: The frequency of CHDs in Down syndrome children from Almadina province in the west of Saudi Arabia was similar to those reported worldwide. The most frequent lesion diagnosed in this study was AVSD. The CHDs were slightly more frequent in Down syndrome children born to consanguineous parents.

show abstract

Section: Discussioncontrasting

confidence: 70%

Congenital Heart Diseases in Saudi Down Syndrome Children: Frequency and Patterns in Almadinah Region

El-Attar¹

2014

Research J. of Cardiology

View full text Add to dashboard Cite

show abstract

“…8 A large number of chromosomal abnormalities such as trisomy 21, 18,and 13 are associated with CHD in 5-8% cases. 9,10 Because of improvement in health care system, more patients are surviving and entering into adulthood. At the same time diagnosis in neonatal period also increased because of awareness among neonatologist about the disease.…”

Section: Discussionmentioning

confidence: 99%

Pattern of Congenital Heart Diseases and Treatment Options in a Bangladeshi Centre: Analysis of 6914 cases from Non-invasive Cardiac Laboratory

Fatema

2017

Cardiovasc. j.

View full text Add to dashboard Cite

Background: Echocardiography is the most sensitive tool to diagnose congenital heart diseases efficiently. It can be repeated as many times as required to see the progress, outcome of treatment and complications. Echocardiography laboratory can give a scenario of pattern of congenital heart diseases existing in Bangladesh as well as natural history of the cases and treatment options offered.Methods: It is a retrospective review of database of echocardiography patient from pediatric noninvasive laboratory of a cardiac hospital from January 2012 to December 2012.Results: Out of 6914 cases 55.73% were male and 44.27% female. Neonates include 8.48%, 36.62% Down Syndrome were infant, 34.02% were under 5 years, 17.97% were children and adolescents and 2.96% were adults. Normal Echocardiography finding was found in 17.28% cases. Ventricular septal defect (VSD) was found in 18.60% cases, Atrial septal defects (ASD) in 15.41% cases, Patent ductus arteriosus (PDA) in 8.59% cases, Atrioventricular septal defect (AVSD) in 1.97% cases, Tetralogy of Fallot (TOF) in 4.79% cases and Transposition of great arteries (TGA) in 2.26% cases. Down syndrome was the commonest chromosomal abnormality seen in 2.4% cases.Conclusion: This study shows that VSD is the commonest congenital heart lesions in our country followed by ASD. Down syndrome was the commonest chromosomal abnormality seen in 2.4% cases.Cardiovasc. j. 2017; 9(2): 97-105

show abstract

“…3,[5][6][7][8][9][10][11][12][13][14][15][16][17] The types of heart defect may vary according to geographic region. In this study, the most common type was atrial septal defect, which was similar to the findings from other Table 1.…”

Section: Discussionmentioning

confidence: 99%

Down syndrome: Prevalence and distribution of congenital heart disease in Brazil

et al. 2015

View full text Add to dashboard Cite

CONTEXT AND OBJECTIVE: Down syndrome is the most common genetic disorder, affecting 1/700 live births. Among the clinical findings, one constant concern is the high prevalence of congenital heart disease. The objective of this study was to determine the prevalence and profile of congenital heart disease among patients attended at a Down syndrome outpatient clinic in southern Brazil between 2005 and 2013. DESIGN AND SETTING: Cross-sectional study conducted in a referral center. METHODS: Data were retrospectively gathered from the medical files of 1,207 patients with Down syndrome, among whom 604 (50.0%) had been diagnosed with congenital heart disease. These data were subjected to descriptive analysis using the Statistica software. RESULTS: Among the 604 patients with congenital heart disease, 338 (55.8%) were male and 269 (44.5%) were female. The most common heart diseases were atrial septal defect in 254 patients (42.1%); total atrioventricular septal defect in 91 (15.1%); atrial septal defect and ventricular septal defect in 88 (14.6%); ventricular septal defect in 77 (12.7%); patent ductus arteriosus in 40 (6.6%); patent foramen ovale in 34 (5.6%) patients; tetralogy of Fallot in 12 (2%); and other diseases in 8 (1.3%). Pulmonary hypertension was present in 57 (9.4%). Out of the total, 150 patients (24.8%) underwent cardiac surgery. CONCLUSION: The high prevalence of congenital heart disease among the patients at the Down syndrome outpatient clinic (50%) was similar to findings from other studies and justifies investigation during the neonatal period, so as to decrease mortality and morbidity. RESUMO

show abstract

Congenital heart disease in children with Downs syndrome: Turkish experience of 13 years

Cited by 36 publications

References 15 publications

Congenital Heart Diseases in Saudi Down Syndrome Children: Frequency and Patterns in Almadinah Region

Congenital Heart Diseases in Saudi Down Syndrome Children: Frequency and Patterns in Almadinah Region

Pattern of Congenital Heart Diseases and Treatment Options in a Bangladeshi Centre: Analysis of 6914 cases from Non-invasive Cardiac Laboratory

Down syndrome: Prevalence and distribution of congenital heart disease in Brazil

Contact Info

Product

Resources

About

Congenital heart disease in children with Downs syndrome: Turkish experience of 13 years

Cited by 36 publications

References 15 publications

Congenital Heart Diseases in Saudi Down Syndrome Children: Frequency and Patterns in Almadinah Region

Congenital Heart Diseases in Saudi Down Syndrome Children: Frequency and Patterns in Almadinah Region

Pattern of Congenital Heart Diseases and Treatment Options in a Bangladeshi Centre: Analysis of 6914 cases from Non-invasive Cardiac Laboratory

Down syndrome: Prevalence and distribution of congenital heart disease in Brazil

Contact Info

Product

Resources

About

Congenital heart disease in children with Downs syndrome: Turkish experience of 13 years