Congenital Heart Disease and Women’s Health Across the Life Span: Focus on Reproductive Issues

Haberer, Kim; Silversides, Candice K.

doi:10.1016/j.cjca.2019.10.009

Cited by 29 publications

(28 citation statements)

References 75 publications

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“…Nevertheless, the rate of incorrect answers was higher for the KSSP questions regarding natural methods of contraception such as utilizing infertile periods in the menstrual cycle. Appropriate sex counseling regarding contraception is generally important given the multiple challenges of pregnancy but also needs to consider an individual’s heart condition where relevant [ 7 , 11 ]. In particular, the high estrogen levels in oral contraceptives increase the risk of thrombosis, and such contraceptives are not recommended for patients with Eisenmenger syndrome and ventricular dysfunction or for those who have undergone valve replacement or a Fontan procedure [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, it is important to create an environment where one can ask medical staff to address individual concerns without the individuals involved feeling ashamed. In addition, for women with CHD, pregnancy can cause hemodynamic changes and complications in their hearts and fetuses; hence, close assessment and education should be provided in conjunction with other departments such as obstetrics and gynecology [ 11 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, there are no accurate data regarding how such knowledge might be acquired, for example, whether through voice channels, the mass media, or the internet. However, appropriate sex counseling regarding contraception is important because unplanned pregnancies can have potentially fatal consequences for fetuses, mothers, or both, and, for those with CHD, recommendations for contraception should be made depending on an individual’s heart condition [ 7 , 11 ]. Healthcare providers in this field, who have previously built rapport and maintained good therapeutic relationships with patients, are likely to be the most appropriate health caregivers to act as educators and counselors to address such patients’ sexual health problems.…”

Section: Introductionmentioning

confidence: 99%

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Sexual health knowledge and needs among young adults with congenital heart disease

Kwon

2021

PLoS ONE

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Advances in the treatment of congenital heart disease (CHD) have increased life expectancy, entailing medical surveillance for a considerable number of adolescents and young adults with CHD for issues arising in areas such as sexual health. This study aimed to assess the sexual knowledge and the needs for sexual health education among this group. The participants comprised 53 young adult outpatients (27 males, median age: 23 years) who had undergone surgical interventions (median: 3 times) for CHD. The Knowledge related to Safe Sex Practice scale (KSSP), an assessment tool containing 15 questions on sexual knowledge, was administered, and the rates of correct answers for each item and the overall scale were compared with the age and sex of a control group (n = 164). The overall mean KSSP score of the participant group (10.5 ± 1.8) was significantly lower than that of the control group (11.1 ± 1.9, p = .035). The KSSP scores of the participants with low peripheral oxygen saturation (SaO2 < 95%) were significantly lower (9.77 ± 1.85) than those with normal SaO2 (11.06 ± 1.85, p = .009). Regarding sexual health education, the participants reported receiving information about contraception as more important than other areas of sexual health. The rate of incorrect answers was higher for questions regarding natural ways of contraception utilizing infertile periods in the menstrual cycle. Based on an informed understanding of those with CHD, healthcare providers in this field should develop customized sexual health education for adolescents and young adults with CHD and implement customized sexual health education, including effective contraception methods.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sexual health knowledge and needs among young adults with congenital heart disease

Kwon

2021

PLoS ONE

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“…However, recent studies have demonstrated that pre-, peri-or post-menopausal hormonal replacement therapies have little effect on the incidence of heart disease (Chester et al, 2018;Chlebowski et al, 2017;Haberer and Silversides, 2019;Mosca et al, 2007;Whayne and Mukherjee, 2015). Furthermore, current studies suggest that a sex-specific program controlled genetically through the X or Y chromosome can function outside of the sex organs (Arnold, 2017(Arnold, , 2019Naqvi et al, 2019;San Roman and Page, 2019;Snell and Turner, 2018).…”

Section: Introductionmentioning

confidence: 88%

“…Though sex plays a critical role in cardiac disease, the mechanisms underlying sex differences in cardiac homeostasis and disease remain unexplained. Sex disparities exist in the anatomy and physiology of the heart as well as in the preponderance of specific types of heart disease (Chester et al, 2018;Chlebowski et al, 2017;Dent et al, 2011;Garcia et al, 2016;Haberer and Silversides, 2019;Mosca et al, 2007;Prabhavathi et al, 2014;Whayne and Mukherjee, 2015;Wu et al, 2019). For example, females have a higher rate of atrial septal defects, while males exhibit a higher rate of aortic arch abnormalities (Arnold et al, 2001;Giannakoulas et al, 2017;Maric-Bilkan et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Cardiac Sex Differences are Established Prior to Gonad Formation

Shi¹,

Sheng

Dorr³

et al. 2020

Preprint

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Male and female disease states differ in their prevalence, treatment responses, and survival rates. In cardiac disease, women almost uniformly fare far worse than men. Though sex plays a critical role in cardiac disease, the mechanisms underlying sex differences in cardiac homeostasis and disease remain unexplained. Here, in adult and embryonic hearts we reveal sex-specific transcriptomes and proteomes and show that cardiac sex differences are predominately accounted for by post-transcriptional mechanisms. We found differential expression of male-female proteins in the cardiomyocytes. Using a quantitative proteomics-based approach, we characterized differential sex-specific enriched cardiac proteins, protein complexes, and biological sex processes in the context of global genetic diversity of the Collaborative Cross, an established surrogate for human diversity. We also found that sex differences in cardiac protein expression are established by both hormonal and sex chromosomal mechanisms. We have demonstrated the onset of sex-biased protein expression and discovered that sex disparities in heart tissue occur at the earliest stages of heart development at a period that preceeds mammalian gonadal development. Collectively, these findings may explain why congenital heart disease, a leading cause of death whose origin is often developmental, is sex biased. Our results reveal molecular foundations for differences in cardiac tissue that underlie sex disparities in health, disease, and treatment outcomes.

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Multidisciplinary care of peripartum heart failure: A scientific statement of the Heart Failure Association of the ESC

Rakisheva,

Sliwa,

Bauersachs

et al. 2024

European J of Heart Fail

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Heart failure is the most common cardiovascular complication during pregnancy and the postpartum period. It is associated with increased risk of maternal morbidity and mortality as well as potentially life‐threatening foetal pathology. Management of heart failure in pregnancy requires expert knowledge of cardiovascular disease as well as obstetrics which underscores the importance of multidisciplinary cardio‐obstetrics teams in order to optimize diagnosis, treatment and outcome. This includes counselling of women at risk before and during the course of pregnancy in order to strengthen the relationship between medical specialists and patients, as well as to allow patient‐centred delivery of care and improve quality of life.

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Congenital Heart Disease and Women’s Health Across the Life Span: Focus on Reproductive Issues

Cited by 29 publications

References 75 publications

Sexual health knowledge and needs among young adults with congenital heart disease

Sexual health knowledge and needs among young adults with congenital heart disease

Cardiac Sex Differences are Established Prior to Gonad Formation

Multidisciplinary care of peripartum heart failure: A scientific statement of the Heart Failure Association of the ESC

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