Congenital Heart Disease and Genetic Changes in Folate/Methionine Cycles
Nataša Karas Kuželički,
Bojan Doljak
Abstract:Congenital heart disease is one of the most common congenital malformations and thus represents a considerable public health burden. Hence, the identification of individuals and families with an increased genetic predisposition to congenital heart disease (CHD) and its possible prevention is important. Even though CHD is associated with the lack of folate during early pregnancy, the genetic background of folate and methionine metabolism perturbations and their influence on CHD risk is not clear. While some gen… Show more
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