Congenital Heart Defects in Live-born Children of Epileptic Parents

Friis, Mogens Laue; Hauge, M.

doi:10.1001/archneur.1985.04060040084018

Cited by 23 publications

(10 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Classification of epileptic seizures and of the epilepsies (Merlis, 1970;Dreifuss et al, 1985), in addition to the complexity of AED treatment, creates major problems in the evaluation of the malformation risk in the offspring of parents with epilepsy. The main purpose of the present author's studies was to elucidate whether the reported association of parental epilepsy and an increased rate of CL(P), CP and CHD in the offspring was due to genetic factors rather than to AED (Friis, 1979;Friis et al, 1981Friis et al, , 1986Friis & Hauge, 1985).…”

Section: Genetic Factors In the Etiology Of Facial Clefts And Congenimentioning

confidence: 96%

“…The author's investigations on an association of congenital heart defects and epilepsy. Friis & Hauge (1985) found 18 cases of CHD among 2461 live-born children of an unselected group of 979 males and 1093 females with epilepsy; 8 CHD children had fathers and 10 had mothers with epilepsy. The prevalence of CHD did not differ significantly in children of epileptic fathers (8 of 1062: 0.75%) or of epileptic mothers (10 of 1399: 0.71 olo), from background population values (Laursen 1979: 0.80%).…”

Section: Review Of the Literature On A Common Geneticmentioning

confidence: 97%

“…Table 5 lists 8 sets of studies of case-controllike design comparing malformation rates in children born to mothers with epilepsy to those in children with fathers having epilepsy. The ratio of CHD rates in children of mothers and fathers with epilepsy range from 0.9 to 4.9 in the studies with a sufficient number of unselected probands (Annegers et al, 1974a(Annegers et al, , b, 1975Annegers & Hauser, 1982;Beck-Mannagetta et al, 1982;Friis & Hauge, 1985;Friis et al, 1986). A number of studies have too few patients to permit analysis (Dieterich et al, 1980;Dansky et al, 1982;Koch et al, 1982Koch et al, , 1983.…”

Section: Studies With a Genuine Control Groupmentioning

confidence: 99%

“…The few negative early reports have been uncontrolled or anecdotal (Hagen, 1969;Bird, 1969). Later the role of epilepsy per se or the epileptic father in the genesis of major congenital malformations in the offspring was focused upon (Fraser & Macgillivray, 1969;Erickson & Oakley, 1974;Saxen, 1975;Friis, 1979;Friis et al, 1981Friis et al, , 1986Annegers & Hauser, 1982;Friis & Hauge, 1985).…”

mentioning

confidence: 99%

See 3 more Smart Citations

Facial clefts and congenital heart defects in children of parents with epilepsy: genetic and environmental etiologic factors

Friis

1989

Acta Neurologica Scandinavica

Self Cite

View full text Add to dashboard Cite

Increased prevalence of cleft lip with or without cleft palate (CL(P], isolated cleft palate (CP), and congenital heart defects (CHD) in children of epileptic mothers have been ascribed to early fetal exposure to antiepileptic drugs (AED). However, common genetic factors responsible for both the malformations in question and the epileptic disorder might be of relevance for the increased rate of CL(P), CP, and CHD, rather than the influence of AED. The present review analyzes the literature on genetic and environmental etiologic factors (i.e. AED and epileptic seizures) that have been reported to increase the rate of CL(P), CP, and CHD in children of parents with epilepsy. Our data suggest that genetic factors are of minor importance for the etiology of facial clefts in offspring of epileptic patients. The rate of facial clefts was increased by a factor of 4.7 in children of AED-treated mothers with epilepsy compared with the background population values. Children of fathers with epilepsy and sibs of epileptic patients had no more facial clefts than expected. The rate of CHD in children of mothers and fathers with epilepsy was comparable to population figures. The role of epileptic seizures as a causative factor for CL(P), CP, and CHD is not settled, but seems to be of limited importance. Areas of future research are outlined concerning the teratogenic role of AED and their metabolites, especially on the postnatal intellectual development of the exposed children. Finally, the need for studies on prophylactic measures as well as the necessity of international surveillance systems on new AED teratogenicity are emphasized.

show abstract

Section: Genetic Factors In the Etiology Of Facial Clefts And Congenimentioning

confidence: 96%

Section: Review Of the Literature On A Common Geneticmentioning

confidence: 97%

Section: Studies With a Genuine Control Groupmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Facial clefts and congenital heart defects in children of parents with epilepsy: genetic and environmental etiologic factors

Friis

1989

Acta Neurologica Scandinavica

Self Cite

View full text Add to dashboard Cite

show abstract

“…The hypothesis that epilepsy per se increases the risk of congenital malformations was originally advanced in a large American and Finnish study (Shapiro et al., 1976). Although some subsequent reports found an increased risk in the absence of antiepileptic therapy or in the children of fathers with epilepsy (Meyer, 1973; Majewski et al., 1981; Beck‐Mannagetta et al., 1982; Koch et al., 1982; Friis & Hauge, 1985; Rating, 1987; Koch et al., 1992), a recent meta‐analysis concluded that there is no increased risk (Fried et al., 2004). The findings of this meta‐analysis, however, should be interpreted with caution given the criteria used to select the studies, the small number of these studies, and their small sample size.…”

Section: Pregnancymentioning

confidence: 99%

Italian Consensus Conference on Epilepsy and Pregnancy, Labor and Puerperium

Aguglia

Barboni²,

Battino

et al. 2009

Epilepsia

View full text Add to dashboard Cite

SUMMARYTo facilitate an integrated and rational approach to the care of women with epilepsy of childbearing potential, a group of experts appointed by Italian scientific societies in the fields of epileptology, neonatology, pediatrics, neuropediatrics, child neuropsychiatry, obstetrics, and gynecology held a joint meeting in Santa Trada di Cannitello, Reggio Calabria, Italy, on October [15][16] 2004, with the aim of reaching consensus on the optimal management of these women. An ad hoc system for the classification of available published evidence and the opinions of experts was developed and used to grade recommendations on different aspects related to counseling, diagnostic, and treatment issues. The present document summarizes available evidence on the reciprocal interactions between epilepsy, antiepileptic drugs, fertility, contraception, pregnancy, delivery, breastfeeding, and the offspring. Recommendations are made concerning the information and counseling that should be provided to women with epilepsy with respect to issues related to contraception, conception, pregnancy, labour, and puerperium. More detailed recommendations on the same issues are provided to physicians and other healthcare professionals involved in the care of these women, with special reference to choice of effective contraception, optimization of antiepileptic drug therapy, use of prenatal diagnostic tests and other monitoring procedures, and appropriate management practices in relation to childbirth, puerperium, and the care of the child. KEY WORDS: Epilepsy, Antiepileptic drugs, Fertility, Contraception, Pregnancy, Puerperium, Clinical management, Consensus paper, Italian League against Epilepsy.The management of women with epilepsy is complex and requires a multidisciplinary approach. However, there is currently no real coordination in Italy among the different professionals involved, and the advice given by the epileptologist will often differ from that given by the gynecologist, neonatologist, or pediatrician. As a result,

show abstract