Congenital Feline Hypothyroidism With Partially Erupted Adult Dentition in a 10-Month-Old Male Neutered Domestic Shorthair Cat: A Case Report

Jacobson, Teresa; Rochette, Judy

doi:10.1177/0898756418785946

Cited by 8 publications

(19 citation statements)

References 14 publications

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“…1994, Mazrier et al . 2003, Jacobson & Rochette 2018), and the new cases here support that hypothyroidism with goitre is the most common form of congenital hypothyroidism in cats.…”

Section: Discussionsupporting

confidence: 69%

“…Non-goitrous cases of congenital hypothyroidism have also been reported in cats, including thyroid hypoplasia and thyrotropin resistance (Tanase et al 1991, Traas et al 2008. Approximately half of all cases of feline congenital hypothyroidism are goitrous (Sjollema et al 1991, Jones et al 1992, Peterson et al 1994, Mazrier et al 2003, Jacobson & Rochette 2018, and the new cases here support that hypothyroidism with goitre is the most common form of congenital hypothyroidism in cats.…”

Section: Discussionsupporting

confidence: 56%

“…Feline hypothyroidism is most frequently an iatrogenic consequence of therapy for hyperthyroidism (Welches et al 1989). Spontaneous hypothyroidism is uncommon, with only 11 cases of adult-onset disease (Rand et al 1993, Blois et al 2010, Galgano et al 2014, Kent et al 2016, Peterson et al 2018 and approximately 65 cases of congenital hypothyroidism reported (Arnold et al 1984, Peterson 1989, Sjollema et al 1991, Tanase et al 1991, Jones et al 1992, Peterson et al 1994, Stephan & Schütt-Mast 1995, Schumm-Draeger et al 1996, Firth et al 2000, Tobias & Labato 2001, Mazrier et al 2003, Crowe 2004, Szabo & Wells 2007, Traas et al 2008, Quante et al 2010, McGhie & Thompson 2011, Lim et al 2014, Peterson 2015, Van Bergen et al 2016, Jacobson & Rochette 2018.…”

Section: Introductionmentioning

confidence: 99%

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Cluster of cases of congenital feline goitrous hypothyroidism in a single hospital

Iturriaga

Cocio

Barrs

2020

J of Small Animal Practice

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To describe the clinicopathological findings and outcomes of cases of feline congenital hypothyroidism diagnosed in a single veterinary hospital in Santiago, Chile. Materials and MethOds: Medical records were searched for cases of congenital hypothyroidism over an 18-month period. Inclusion criteria were a diagnosis of congenital hypothyroidism based on consistent historical and clinical findings, a low or low-normal serum total T4 and elevated serum canine TSH (cTSH). results: Six unrelated cats ranging in age from 4 to 19 months met the inclusion criteria. The most common historical signs were small stature and lethargy. All cats had disproportionate dwarfism, delayed tooth eruption, retained deciduous teeth, bilateral palpable goitres and low rectal temperatures. Other findings were bradycardia, obesity, poor hair coat and focal alopecia on the ventral aspects of the elbows and hocks. In all cases, cTSH was markedly elevated. Sequential changes noted after the initiation of therapy included normal T4 after 6 weeks, improved hair coat and increased physical activity by 8 weeks, normal cTSH by 10 weeks and normal physical appearance and dentition after 4 months. Goitres shrank markedly but remained palpable. Hypothyroidism was well managed clinically in all cases 2 years after diagnosis except for one cat that died of unrelated causes. clinical significance: This is the first report to describe a cluster of congenital hypothyroidism cases in non-related cats that were presented over a short period of time. Growth defects resolve with treatment, even in cats diagnosed after puberty. Larger, prospective multi-centre studies are warranted to determine the incidence of congenital hypothyroidism in cats.

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“…1994, Mazrier et al . 2003, Jacobson & Rochette 2018), and the new cases here support that hypothyroidism with goitre is the most common form of congenital hypothyroidism in cats.…”

Section: Discussionsupporting

confidence: 69%

Section: Discussionsupporting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cluster of cases of congenital feline goitrous hypothyroidism in a single hospital

Iturriaga

Cocio

Barrs

2020

J of Small Animal Practice

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“…The main reasons for this postulate are two: (1) high concentrations have been reported in all of the congenitally hypothyroid cats previously described, and (2) falsely high values for TSH are not generally seen in cats with non-thyroidal illness [ 1 ]. Although the pathophysiological mechanisms, clinical aspects, diagnostic methods, and initial treatment for CH cats have been investigated in several reports [ 3 , 4 , 6 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ], a complete long-term follow-up has rarely been described [ 3 , 6 , 10 , 16 , 25 ].This case series describes the body weight, clinicopathological and radiographic changes after early diagnosis, and the one-year treatment follow-up of three kittens with CH.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Weight Gain, Clinicopathological and Radiographic Changes after Early Diagnosis and Treatment of Congenital Hypothyroidism in Cats

Golinelli¹,

Tardo²,

Vecchiato³

et al. 2022

Veterinary Sciences

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Congenital hypothyroidism is uncommon in cats. This case report describes weight gain, clinicopathological and radiographic changes after early diagnosis and treatment of congenital hypothyroidism in three British shorthair cats’ siblings. Data were assessed at 53 (diagnosis), 83, 185 and 365 days of age. Correlations between serum insulin-like growth factor-1 (IGF-1) and body weight, levothyroxine dose, total thyroxine, and thyroid-stimulating hormone concentrations were evaluated. The body weights of the congenital hypothyroid kittens were compared with those of their two healthy siblings and British shorthair kittens of the same age. At diagnosis, the congenital hypothyroid kittens showed a significantly lower body weight compared to the healthy siblings (p = 0.03). After diagnosis, oral levothyroxine supplementation was started. The difference in body weight was no longer observed after one month of treatment. The clinical signs, clinicopathological and radiographic abnormalities ameliorated after one month of treatment. IGF-1 concentration was significantly positively correlated with body weight (rs = 0.80, p < 0.002). In conclusion, resolution of the clinical signs, achieving a consistent within-breed weight, and improvement of the clinicopathological and radiographic parameters demonstrated the importance of the early diagnosis and treatment of feline congenital hypothyroidism.

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“…Lorestan province is located in the western part of Iran, between 46° 51′ to 50° 3′ east of the Greenwich meridian (Hashemipour et al, 2004), and 32° 37′ to 34° 22′ north latitude from the equator (Ordookhani, Minniran, Najafi, Hedayati, & Azizi, 2003). According to the definition of WHO, if there is a high Thyroid-stimulating-hormone (TSH) in the neonate sample in more than 3% of cases, there is a deficiency of iodine (Jacobson & Rochette, 2018;Kışlal, Çetinkaya, Dilmen, Yaşar, & Teziç, 2010). National prevalence of CHD is 1 per 370-1,000 live births, and the mean of 428 cases in 100,000 live births (Zeidan et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

A 10‐year prevalence of congenital hypothyroidism in Khorramabad (Urban Western Iran)

Taee

Goodarzi

Safdari

et al. 2019

Molec Gen & Gen Med

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Background Congenital hypothyroidism in infants is the cause of mental retardation in children, it can be detected in patient and treated at a relatively cheap rate, preventing patient retard. This study aimed to determine the prevalence of congenital hypothyroidism among Khorramabad children. Methods In the present study, we identified all patients who had received levothyroxine prescriptions during the study period (2007–2017). Using this as a congenital hypothyroidism surrogate marker, we considered the congenital hypothyroidism prevalence in children above 3 years. Results Of 574 patients who had received levothyroxine during the neonatal period up to 3 years, the results of one‐variable logistic regression analysis showed that the chance of temporary disease in children with small thyroid ultrasonography was 62% less, than for those without problems, and this difference was significant. The chance of temporary disease in children who had other cases was 87% less than those without problems, and this difference was statistically significant. Conclusion The overall prevalence of congenital hypothyroidism in young patients up to 3 years is 0.143%, these values are at least twice those of previous estimates. This proposes an elevation in autoimmune thyroid disease, which is similitude to the rising prevalence of diabetes type 1, which possibly indicates a rising incidence of autoimmunity in youth.

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Congenital Feline Hypothyroidism With Partially Erupted Adult Dentition in a 10-Month-Old Male Neutered Domestic Shorthair Cat: A Case Report

Cited by 8 publications

References 14 publications

Cluster of cases of congenital feline goitrous hypothyroidism in a single hospital

Cluster of cases of congenital feline goitrous hypothyroidism in a single hospital

Evaluation of Weight Gain, Clinicopathological and Radiographic Changes after Early Diagnosis and Treatment of Congenital Hypothyroidism in Cats

A 10‐year prevalence of congenital hypothyroidism in Khorramabad (Urban Western Iran)

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