Congenital Ectodermal Defect in Miniature Poodles

An overview on congenital alopecia in domestic animals

“…A comparable phenotype exists in humans, where the multifocal lack of hair follicles is associated with a complete lack of apocrine glands resulting in impaired thermoregulation. 47 A disease analogous to anhidrotic ectodermal dysplasia in man has repeatedly been described in various breeds of dogs, [48][49][50][51][52][53] although not all cases have accurately been classified at the time of publication. [54][55][56][57][58][59] Comparable to mice and humans, this form of ectodermal dysplasia in dogs is a recessive X-linked trait and as such primarily occurs in males, although very rare cases in females are possible because of inactivation (lyonization) of the unaffected allele.…”

“…61 In cattle, congenital hypotrichosis associated with severe dental abnormalities (also called 'hypotrichosis and anodontia defect') has been described in several breeds. 48,49,62,[64][65][66][67][68][69] Other reports of hypotrichosis and dental dysplasia in cattle are probably also variants of anhydrotic ectodermal dysplasia. 70,71 As in humans, mice, and dogs, the disease shows an X-linked monogenetic recessive inheritance and primarily occurs in male calves.…”

“…99,100 This 'congenital progressive alopecia in Polled Hereford cattle' is probably the same condition that is known as 'semihairlessness'. 48,49,[101][102][103][104] Calves have wiry and kinked or curled hair fibres at birth and present with alopecia over the bridge of the nose and the ears. Within weeks, alopecia progresses and affects head, lateral neck, shoulders and dorsal lumbar areas.…”

Generalized Congenital Hypotrichosis in a Female Rottweiler

“…Lack of hair may be the only abnormality noted or may be seen concomitantly with other ectodermal defects such as abnormal dentition and decreased tear production ( 1-6). Congenital hypotrichosis has been previously documented convincingly in the whippet ( l), cocker spaniel (2), Belgian shepherd dog (3), lhasa apso (5), miniature poodle (7), basset hound (8), beagle (9), labrador retriever (9), bichon frise (10) and the Yorkshire terrier ( I 1). All previous reports of this syndrome, with the exception of a female labrador retriever reported by Kunkle (9) have been in male dogs implying sex-linked inheritance.…”

Identification of erythrocytic types in dogs by antisera and lectins

“…A short paper by Dudok et al (1967) The first possible linkage of dog blood groups with nonblood group characters was found by Selmanowitz et al (1970) who studied a hair defect in poodles. Two affected male littermates had the same blood type, which differed from that of the dam or sisters.…”