Congenital dyserythropoietic anemia type II (CDA II) diagnosed in an adult patient

Abstract

The congenital dyserythropoietic anemias (CDAs) are a group of rare hereditary disorders characterized by ineffective erythropoiesis and distinct morphologic

Complications of Delayed Diagnosis and Challenges: Hereditary Spherocytosis with Hepatocellular Jaundice, a Case Report from Ethiopia

“…Clinical judgment and interpretation of laboratory results based on clinical context are crucial. In the absence of a family history and a normal reticulocyte count, congenital dyserythropoietic anemia (CDA type 2) should be taken into account because of its analogous clinical pro le to HS 10 . Thus in patients with atypical features genetic testing is essential 8 .…”

Modeling congenital dyserythropoietic anemia in genetically modified mice

“…The most striking morphological feature of CDA 2 is the presence of binucleated cells with both nuclei at the same stage of erythroid maturation. Morphologically, the diagnosis of CDA 2 is definite when at least 10% of erythroblasts are binucleated, with over 2% of the cells having a fragmented nucleus and irregular chromatin distribution in the cytoplasm [17,32]. A discontinuous double membrane is present in the mature CDA 2 erythroblasts in electron microscopy, which is likely formed by large vesicles or cisterns of the ER that are positioned just below the plasma membrane [16].…”

Two cases of microcytic hypochromic anemias albiet not iron deficiency but iron excess

“…A diagnosis of Congenital dyserythropoeitic Anemiatype II (CDA-II) was suggested after a positive result on acid hemolysis test (HAM test) with recommendation for iron chelation and splenectomy. [2] Case 2: A 47 year old male presented with di culty in breathing, generalised weakness and fever. The hematological, biochemical and radiological ndings were those of a hemolytic anemia similar to case 1.…”