Congenital Diaphragmatic Hernia and Growth to 12 Years

Abstract

Poor linear growth persisted at 12 years of age. The pattern of early deterioration of weight gain followed by a decline in linear growth is suggestive of inadequate nutrition during infancy. Therefore, nutritional assessment and intervention should be started early and should be continued during childhood.

Genetic analysis ofde novovariants reveals sex differences in complex and isolated congenital diaphragmatic hernia and indicatesMYRFas a candidate gene

“…In the combined cohort, there were 210 (59%) male and 147 (41%) female CDH patients. The gender distribution with increase male prevalence (1.4:1) is consistent with published retrospective and prospective studies 15, 16 . Among the 148 complex cases, the most frequent anomalies were congenital heart disease (41%), but neurodevelopmental delay, gastrointestinal, and other malformations were common (Table 1 and Supplementary Table 2).…”

Nutrition Support During Pediatric Extracorporeal Membrane Oxygenation

“…This trend continued into adolescence, demonstrating stunting in both groups that was most severe in the ECMO population. Notably, none of the patients were feeding tube dependent by 8 years of age . This study highlights the ongoing nutrition challenges of children with CDH and the need for close follow‐up and multidisciplinary interventions.…”

Defining outcomes following congenital diaphragmatic hernia using standardised clinical assessment and management plan (SCAMP) methodology within the CDH EURO consortium

“…22 Approximately 20-30% experience FTT within the first few years of life which may persist into adolescence. 87,88 However, Gien et al 89 revealed the highest risk for comorbidities at both extremes of growth velocity. Leeuwen et al 88 observed stunting and wasting up to 12 years of age, although growth failure became less prevalent after correcting for individual target height.…”

“…87,88 However, Gien et al 89 revealed the highest risk for comorbidities at both extremes of growth velocity. Leeuwen et al 88 observed stunting and wasting up to 12 years of age, although growth failure became less prevalent after correcting for individual target height. Several risk factors expressing the severity of CDH have been identified: the intensity of respiratory support, ECMO use, and oxygen supplementation at discharge.…”