Congenital Dermoid Fistula of the Anterior Chest Region.

Matsunaga, Wakatoshi; Ishihara, Tsuyoshi; Yasuno, Kayoko

doi:10.2336/nishinihonhifu.56.34

Cited by 22 publications

(29 citation statements)

References 7 publications

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“…We conjecture that the authors who insisted that the fistula was a dermoid fistula may not A c c e p t e d M a n u s c r i p t have kept the existence of the fourth branchial cleft remnant in mind because they were all dermatologists and may not have been familiar with branchial anomalies. The clinical characteristics of our case series were similar to those of the previously-reported cases (8)(9)(10)(11). However, our cases differed from a dermoid fistula with regard to the following points: 1) A dermoid fistula is usually situated on the midline of the body, and our case and the previously-reported cases were not situated on the midline.…”

Section: Resultscontrasting

confidence: 47%

“…3-b). 3) Among all reported cases (8)(9)(10)(11) as well as our cases, the lesions were predominantly situated on the left side, which strongly suggested that the fistula was related to the fourth branchial remnant fistula.…”

Section: Resultsmentioning

confidence: 62%

“…Histopathological examination of the epithelial layer of the fistulas revealed that most cases had a stratified squamous epithelium (case 1-6) and four of them had an epidermal appendage such as a sebaceous gland, hair follicle or sweat gland (case 2-5) Four papers previously reported a very similar cutaneous fistula and all of them were published in dermatology journal (8)(9)(10)(11). Those reports concluded that the fistulas were derived from ectodermal origin and they were designated as a dermoid fistula.…”

Section: Resultsmentioning

confidence: 93%

See 2 more Smart Citations

Congenital cutaneous fistula at the sternoclavicular joint – Not a dermoid fistula but the remnant of the fourth branchial (pharyngeal) cleft ?

Ohno

Kanamori

Tomonaga

et al. 2015

International Journal of Pediatric Otorhinolaryngology

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Section: Resultscontrasting

confidence: 47%

Section: Resultsmentioning

confidence: 62%

Section: Resultsmentioning

confidence: 93%

See 1 more Smart Citation

Congenital cutaneous fistula at the sternoclavicular joint – Not a dermoid fistula but the remnant of the fourth branchial (pharyngeal) cleft ?

Ohno

Kanamori

Tomonaga

et al. 2015

International Journal of Pediatric Otorhinolaryngology

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“…Total excision ofthe fistulous tract is necessary for the optimal management of this condition because recurrence is frequently reported (1,2). Total excision ofthe fistulous tract is necessary for the optimal management of this condition because recurrence is frequently reported (1,2).…”

Section: Discussionmentioning

confidence: 99%

Congenital Dermoid Fistula of the Anterior Chest Region

Numajiri

Nishino²,

Uenaka³

et al. 2008

Acta Derm Venerol

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“…Tolerance of the drug at higher doses is usually determined by its haematological side-effects, viz haemolysis and methaemoglobinaemia (1). These adverse effects are due entirely to hepatic Nhydroxylation of the drug to a hydroxylamine metabolite, some of which escapes from the liver and rapidly enters red cells (1).…”

mentioning

confidence: 99%

Full Dapsone Dose Made Possible by Control of Anaemia with Darbepoetin-alpha

Flosadóttir¹,

Bjarnason²

2008

Acta Derm Venerol

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Sir, Dapsone is a first-line immunosuppressive treatment for many inflammatory diseases. Tolerance of the drug at higher doses is usually determined by its haematological side-effects, viz haemolysis and methaemoglobinaemia (1). These adverse effects are due entirely to hepatic Nhydroxylation of the drug to a hydroxylamine metabolite, some of which escapes from the liver and rapidly enters red cells (1). We describe here a case in which dapsoneinduced haemolysis was treated with darbepoetin-alpha. CASE REPORTAn 84-year-old man presented who had had symblepharon and entropion that had required multiple operations, but with poor results. He also had oral mucosal lesions and desquamative gingivitis, both of which affected his sleep and eating habits. His dentist referred him to us because he noticed a lesion in the skin. Linear IgA disease was suspected and confirmed by .typical histopathological changes showing subepidermal blistering with predominant neutrophilic infiltrate in the upper dermis and immunofluorescent staining showing linear deposition of IgA at the basal membrane zone. He was initiated cautiously on 25 mg of dapsone daily, due to his age. In a few days his haemoglobin level fell from 121 g/1 to 107 g/1. There was no therapeutic effect and the dose was increased to 50 mg dapsone daily, but his haemoglobin level fell further, to 98 g/1. The patient became pale with cyanotic lips, but not icteric (total bilirubin 12 Hmol/1, haptoglobin 2.07 g/1, se-lactate dehudrohenase (LDH) 266 U/1 (ref value 240-480 U/1), mean corpuscular volume (MCV) 98 fl, se-B12 375 pmol/1, erythrocyte folate 3596 nmol/1, se-iron 10 nmol/1 and se-total iron binding capasity (TIBC) 52 |imol/l). He experienced severe tiredness and instability when walking, and the lesions improved only minimally on that dose. We reduced the dose to an average daily dose of 37.5 mg (alternating 50 mg one day and 25 mg the next) and the lesions became worse. In order to treat the anaemia, we considered darbepoetin-alpha which is a hyperglycosylated derivative of erythropoietin (2) with a threefold longer terminal half-life (3). We administered 50 |ig s.

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Congenital Dermoid Fistula of the Anterior Chest Region.

Cited by 22 publications

References 7 publications

Congenital cutaneous fistula at the sternoclavicular joint – Not a dermoid fistula but the remnant of the fourth branchial (pharyngeal) cleft ?

Congenital cutaneous fistula at the sternoclavicular joint – Not a dermoid fistula but the remnant of the fourth branchial (pharyngeal) cleft ?

Congenital Dermoid Fistula of the Anterior Chest Region

Full Dapsone Dose Made Possible by Control of Anaemia with Darbepoetin-alpha

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