The sudden death (SD) of a young subject or athlete, though rare, is a tragic event, which devastates families, institutions (high school, college, or professional organization), the community, and sports medicine team. It is widely publicized by media with the implication that such a fatality is preventable. The beginning of the year 2018 was notorious for SD in young athletes, with three tragic events occurring in top-level athletesincluding a 31-year-old Italian soccer player, a 25-yearold Croatian soccer player, and a 22-year-old Belgian cyclist. These events have revived the debate regarding the need for a cardiovascular evaluation of young individuals embarking on the career of athletes and the best screening protocol.The most common mechanism of cardiac arrest leading to SD is abrupt ventricular fibrillation as a consequence of an underlying cardiovascular disease.
1The culprit diseases are often clinically silent and unlikely to be suspected or diagnosed on the basis of spontaneous symptoms.2 The long-running Italian experience with medical evaluation of young individuals before their participation in sports has provided compelling evidence that screening the young populations for at-risk cardiac diseases offers the potential to identify asymptomatic athletes who have potentially lethal cardiovascular abnormalities and may protect them from the risk of SD. 3 This article reviews the epidemiology, the causes and the mechanisms of SD in young people and athletes and addresses risk stratification and prevention strategies.
Epidemiology IncidenceThe assessment of the precise frequency of SD is hampered by the retrospective nature of most analyses. The risk of SD generally increases with age and is greater in men. In the general population of middle-age and elderly subjects the estimated rate of SD ranges from 1-2/1000/year; in comparison, a significantly lower incidence of fatal events has been reported in young people and athletes (≤35 years).
3-29A prospective study in Italy reported a cumulative annual incidence of SD of about 1 per 100,000 young individuals.3 Among the non-athletic young people the incidence was 0.9/100,000/year, whereas the prevalence of fatalities among young competitive
Sudden cardiac death in young people and athletes
ABSTRACTThe sudden death of a young subject or athlete is a rare but tragic event. The most common mechanism of cardiac arrest leading to sudden death is abrupt ventricular fibrillation as a consequence of an underlying cardiovascular disease. The culprit diseases are often clinically silent and unlikely to be suspected or diagnosed on the basis of spontaneous symptoms. The longrunning Italian experience with medical evaluation of young individuals before their participation in sports has provided compelling evidence that screening the young populations for at-risk cardiac diseases offers the potential to identify asymptomatic athletes who have potentially lethal cardiovascular abnormalities and may protect them from the risk of sudden death. In this review we wil...