Congenital coronary aneurysms with angina pectoris and myocardial infarction treated with saphenous vein bypass graft

Mattern, Allan L.; Baker, William P.; McHale, James J.; Lee, Dixon E.

doi:10.1016/0002-9149(72)90019-7

Cited by 73 publications

(29 citation statements)

References 8 publications

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“…It has been shown that isolated diffuse CAE may be associated with myocardial perfusion abnormalities and reduced coronary flow reserve as documented by TIMI frame counts and myocardial blush grade methods [7,8]. In addition to these, it may cause angina pectoris and myocardial ischemia [9,10].…”

Section: Introductionmentioning

confidence: 99%

Mean platelet volume in patients with isolated coronary artery ectasia

Bitigen

Tanalp²,

Elönü

et al. 2007

J Thromb Thrombolysis

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Coronary artery ectasia (CAE) is frequently considered to be an incidental angiographic finding; however, several reports have shown an association with myocardial ischemia and infarction. In this study, we aimed to evaluate the mean platelet volume (MPV), which is a marker of platelet reactivity, in patients with isolated CAE. In this study we investigated the platelet functions by MPV measurement in patients with isolated CAE. The study population consisted of 23 patients (17 males, 6 females) with isolated CAE (Group-I). Sex-age matched 30 patients (22 males, 8 females) with angiographically proven normal coronary arteries served as the control group (Group-II). Serum total cholesterol, HDL-C, LDL-C, triglyceride level, hemoglobin, white blood cell count, CRP, platelet count and MPV were compared in both groups. There was no significant difference between two groups in terms of age, gender, body mass index, blood pressure and heart rate. Serum total cholesterol, HDL-C, LDL-C, triglyceride level, hemoglobin, white blood cell count, platelet count were also similar in both groups. However, the MPV values of patients with isolated CAE were significantly higher than those of controls (P < 0.0001). In addition to that, CRP levels were found to be significantly higher in patients with isolated CAE (P < 0.002). Increased MPV may indicate the altered platelet reactivity and aggregation and thereby may be associated with ischemic events, observed in patients with isolated CAE.

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Section: Introductionmentioning

confidence: 99%

Mean platelet volume in patients with isolated coronary artery ectasia

Bitigen

Tanalp²,

Elönü

et al. 2007

J Thromb Thrombolysis

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14] We therefore evaluated a large group of patients with aneurysmal coronary disease from the registry data of the multiinstitutional Coronary Artery Surgery Study (CASS), sponsored by the National Institutes of Health (NIH). 5 We examined the clinical and historical features and the natural history of coronary aneurysmal disease to determine whether it represents a distinct clinical entity or a variant of coronary atherosclerotic disease.…”

mentioning

confidence: 99%

Aneurysmal coronary artery disease.

Swaye¹,

Fisher²,

Litwin³

et al. 1983

Circulation

866

816

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To examine the clinical and historical features and the natural history of aneurysmal coronary disease, we reviewed the registry data of the Coronary Artery Surgery Study (CASS). Nine hundred seventy-eight patients, representing 4.9% of the total registry population, were identified as having aneurysmal disease. No significant differences were noted between aneurysmal and nonaneurysmal coronary disease patients when features such as hypertension, diabetes, lipid abnormalities, family history, cigarette consumption, incidence of documented myocardial infarction, presence and severity of angina, and presence of peripheral vascular disease were examined. In addition, no difference in 5-year medical survival was noted between these two groups. These findings suggest that aneurysmal coronary disease does not represent a distinct clinical entity but is, rather, a variant of coronary atherosclerosis.

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“…In patients with mixed CAE, Swanton et al (8) reported similar histological appearance to that of atherosclerosis with marked destruction and reduction of the medial elastic fibers with disruption of the internal and external elastic laminate. On the other hand, the pure form of CAE showed smooth muscle hyalinization of the coronary fibro-muscular media leaving the intima intact (9). This finding were taken further by Fukuda et al (10) and Johanning et al (11) who related the hyalinization process to excessive nitric oxide (NO) production.…”

Section: Discussionmentioning

confidence: 95%

Coronary artery ectasia as a culprit for acute myocardial infarction: review of pathophysiology and management

Boles¹,

Rakhit²,

Shiu³

et al. 2013

Anadolu Kardiyol Derg

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Coronary artery ectasia (CAE) is defined as localized coronary dilatation, which exceeds the diameter of normal adjacent segments or the diameter of the patient's largest coronary vessel by 1.5 times. The pathophysiology of CAE remains unclear as its relationship with atherosclerosis remains only modestly established. The histological variances and conflicting reports of the role of traditional cardiovascular risk factors, also, weakens the significance of such association. The slow coronary flow (CSF) of CAE may lead to ischemic and thrombotic events, a mechanism that has never been fully elucidated, but may play a fundamental role in its pathogenesis. While pure, non-atherosclerotic, CAE is believed to have better prognosis when compared to atherosclerotic obstructive CAE, it is thought that CAE is not a simple condition but rather has an adverse clinical course. Nevertheless, long-term prognosis and outcome of CAE is similar to atherosclerotic-non-CAE. Since CAE was first described, oral anticoagulants have been considered as a valid treatment option. Dual antiplatelet therapy is widely employed in acute coronary syndrome (ACS), which also applies to CAE patients presenting with ACS. However, there is a significant uncertainty about the best treatment strategy for CAE in acute myocardial infarction. We hereby report a variety of presentations of CAE complicated with ST elevation myocardial infarction (STEMI). Pathophysiological and anatomical varieties of ectatic coronary culprit lesions represent clinical challenges in uniformly managing this condition. Our review is unique in critically showing the pathophysiology, available controversial evidence upon management and prognostic features of CAE with STEMI. (Anadolu Kardiyol Derg 2013; 13: 695-701)

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Congenital coronary aneurysms with angina pectoris and myocardial infarction treated with saphenous vein bypass graft

Cited by 73 publications

References 8 publications

Mean platelet volume in patients with isolated coronary artery ectasia

Mean platelet volume in patients with isolated coronary artery ectasia

Aneurysmal coronary artery disease.

Coronary artery ectasia as a culprit for acute myocardial infarction: review of pathophysiology and management

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