Congenital CMV infection in symptomatic infants in Delhi and surrounding areas

Abstract

Many viral infections are associated with significant maternal and fetal consequences during pregnancy among which cytomegalovirus is one of the most important agent, globally. Both primary and recurrent infection due to this virus can result in fetal infection. Samples from Congenital Anoammaled babies are referred to NICD from Delhi based Government hospitals and surrounding areas for diagnosis of congenital infections like Toxoplasm, Rubella, CMV and Herpes. In the present study, accumulated data is presented for the most common teratogenic virus--Cytomegalovirus prevalence as a causative agent for congenital infection in New Born babies at Delhi and surrounding areas. 96 samples from symptomatic babies in the age group of few days to 6 months exhibiting different congenital anomalies, were reported between 1 st Jan 04 to 30 th April/05. All the blood samples were tested for the detection of CMV (IgM) antibodies using m-capture ELISA technique. 18(18.75%) samples from babies showed positive titres for CMV-IgM antibodies. None of the mothers of positive babies were found positive for CMV-IgM antibodies but all were serologically exposed to CMV virus previously as their serum samples were positive for CMV-IgG antibodies indicating primary infection in the past or reactivation/reinfection with a different strain of CMV in the early pregnancy.

Seroprevalence and Influence of Torch Infections in High Risk Pregnant Women: A Large Study from South India

“…Serological surveys in different parts of India have shown 80-90 % prevalence of CMV IgG antibodies in women of childbearing age [48]. In the present study, 92 % of HRP women were positive for IgG only, indicating remote infection while 5 % were positive for both IgG ?…”

Congenital CMV Infection; Diagnosis in Symptomatic Infants

“…A few studies have shown the high prevalence of CMV as the etiological agent in babies born with birth defects. [6][7][8] The rapid and correct diagnosis of congenital CMV congEnItal cmv InfEctIon; dIagnosIs In sYmPtomatIc Infants…”

Screening for Cytomegalovirus Infection During Pregnancy in a Teaching Hospital, Western province, Sri Lanka

“…Conversely, IgG -low avidity antibodies together with reactive CMV IgM strongly support the diagnosis of maternal primary infection in the preceding 3 or 4 months 26,27 . India has higher seroconversion rate (2%-2.5%) among pregnant population, whereas only one sample (0.25%) showed low affinity antibodies indicating primary infection 19,20 . Equivocal results were found in 2.75% of IgG positive samples.…”

“…Seropositivity rates lie between 50%-60% in developed countries, and the rates are between 90%-100% in developing countries 19,20 . CMV seropositivity rates are higher in women of reproductive age especially in low socioeconomic status.…”

“…CMV seropositivity rates are higher in women of reproductive age especially in low socioeconomic status. In different parts of India, serological surveys have shown 80-90% prevalence of CMV IgG antibodies in women of childbearing age 19,20 . However, in some of European countries, low CMV infection rates have been reported, Australia (56.9%) and France (46.8%) 21 .…”