Congenital cataracts following total parenteral nutrition (TPN) use during pregnancy

Heerasing, Neel; Dowling, Damian

doi:10.1038/ejcn.2014.103

Cited by 3 publications

(2 citation statements)

References 11 publications

(16 reference statements)

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“…Only 2 neonates were born prematurely, with 1 suffering from minor facial deformities and acute respiratory distress syndrome 10 . Still, various adverse fetal outcomes most likely linked to micronutrient deficiencies have been reported 12 , 15 , 20 . Specifically, deficiencies in fat‐soluble vitamins have resulted in congenital anomalies, as seen in several patients with intestinal malabsorption 15 , 25 .…”

Section: Discussionmentioning

confidence: 99%

“…In a systematic literature review, we identified 14 publications describing 15 cases of parenteral nutrition from preconception to delivery in 14 women dependent on long‐term HPN 7 – 20 . Here, we additionally report the case of a 26‐year‐old Caucasian woman with SBS secondary to recurrent thromboembolic mesenteric infarctions receiving both HPN and high‐dose dual anticoagulation throughout pregnancy and beyond.…”

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confidence: 99%

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Conception, Pregnancy, and Lactation Despite Chronic Intestinal Failure Requiring Home Parenteral Nutrition

et al. 2015

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Taking the reported literature into consideration, we conclude that under the premise of optimal medical care, the risk:benefit ratio for pregnancy of HPN-dependent women seems to be justifiable. To minimize the risks, we recommend preconception counseling and early referral to a tertiary center offering both a high-risk pregnancy unit and a nutrition service. In particular, maternal micronutrient levels should be monitored.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Conception, Pregnancy, and Lactation Despite Chronic Intestinal Failure Requiring Home Parenteral Nutrition

et al. 2015

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Nongenetic risk factors for infantile cataracts: Systematic review of observational studies

Nalbandyan

Papadopoulos

Leckman‐Westin

et al. 2021

Birth Defects Research

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Introduction While infantile cataracts are a major cause of childhood blindness, risk factors remain unknown for approximately two‐thirds of cases. Methods We systematically searched electronic databases PubMed, Ovid MEDLINE, Web of Science, and Scopus, from inception through March 2018, to identify relevant cohort, case–control, cross‐sectional studies, case reports, and case series. We also manually screened bibliographies and consulted with experts in the field to identify additional publications. We reviewed cross‐sectional studies, case reports, and case series and provided a narrative summary of the reported potential risk factors. We evaluated methodological qualities of cohort and case–control studies, extracted relevant data, and described statistically significant associations with infant, maternal, and paternal characteristics. Quality assessment and data extraction were conducted by two reviewers independently. All discrepancies were discussed with the senior author and resolved by consensus. Results Overall, 110 publications were included in the review, 33 of which were cohort and case–control studies. Most of these studies (n = 32) used population‐based data and had either excellent (n = 31) or good (n = 2) methodological quality. Nine studies reported statistically significant associations with infant characteristics (preterm birth, low birth weight), maternal occupations and diseases during pregnancy (untreated hypertension, infections), and paternal sociodemographics (younger age, employment in sawmill industry during pregnancy). Conclusions This systematic literature review provided a comprehensive summary of the known nongenetic risk factors for infantile cataracts, identified gaps in the literature, and provided directions for future research. Studies identifying modifiable risk factors are warranted to design interventions aimed at primary prevention of infantile cataracts.

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Pregnancy is possible on long-term home parenteral nutrition in patients with chronic intestinal failure: Results of a long term retrospective observational study

et al. 2017

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Congenital cataracts following total parenteral nutrition (TPN) use during pregnancy

Abstract: We describe a case of congenital cataracts in a newborn whose mother received total parenteral nutrition (TPN) throughout her pregnancy. We discuss the potential mechanisms by which TPN may have been causally linked to cataract formation.

Cited by 3 publications

References 11 publications

Conception, Pregnancy, and Lactation Despite Chronic Intestinal Failure Requiring Home Parenteral Nutrition

Conception, Pregnancy, and Lactation Despite Chronic Intestinal Failure Requiring Home Parenteral Nutrition

Nongenetic risk factors for infantile cataracts: Systematic review of observational studies

Pregnancy is possible on long-term home parenteral nutrition in patients with chronic intestinal failure: Results of a long term retrospective observational study

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