Congenital arrector pili hamartoma. A case report and review of the spectrum of Becker's melanosis and pilar smooth-muscle hamartoma

Slifman, Nancy R.

doi:10.1001/archderm.121.8.1034

Cited by 39 publications

(26 citation statements)

References 13 publications

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“…Histologically there is a band-like infiltrate of mature pilar smooth muscle extending from dermis to the superficial subcutis ( Figure 1). [1][2][3][4][5][6][7][8][9] Smooth muscle hamartoma of the breast parenchyma entails bundles of non-atypical smooth muscle present within the breast parenchyma between the lobules, often along with fibrous stroma and scattered fat cells. 10 …”

Section: Smooth Muscle Hamartomamentioning

confidence: 99%

Smooth muscle tumors of soft tissue and non-uterine viscera: biology and prognosis

Miettinen

2014

Modern Pathology

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Smooth muscle tumors are here considered an essentially dichotomous group composed of benign leiomyomas and malignant leiomyosarcomas. Soft tissue smooth muscle tumors with both atypia and mitotic activity are generally diagnosed leiomyosarcomas acknowledging potential for metastasis. However, lesions exist that cannot be comfortably placed in either category, and in such cases the designation 'smooth muscle tumor of uncertain biologic potential' is appropriate. The use of this category is often necessary with limited sampling, such as needle core biopsies. Benign smooth muscle tumors include smooth muscle hamartoma and angioleiomyoma. A specific category of leiomyomas are estrogen-receptor positive ones in women. These are similar to uterine leiomyomas and can occur anywhere in the abdomen and abdominal wall. Leiomyosarcomas can occur at any site, although are more frequent in the retroperitoneum and proximal extremities. They are recognized by likeness to smooth muscle cells but can undergo pleomorphic evolution ('dedifferentiation'). Presence of smooth muscle actin is nearly uniform and desmin-positivity usual. This and the lack of KIT expression separate leiomyosarcoma from GIST, an important problem in abdominal soft tissues. EBVassociated smooth muscle tumors are a specific subcategory occurring in AIDS or post-transplant patients. These tumors can have incomplete smooth muscle differentiation but show nuclear EBER as a diagnostic feature. In contrast to many other soft tissue tumors, genetics of smooth muscle tumors are poorly understood and such diagnostic testing is not yet generally applicable in this histogenetic group. Leiomyosarcomas are known to be genetically complex, often showing 'chaotic' karyotypes including aneuploidy or polyploidy, and no recurrent tumor-specific translocations have been detected.

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Section: Smooth Muscle Hamartomamentioning

confidence: 99%

Smooth muscle tumors of soft tissue and non-uterine viscera: biology and prognosis

Miettinen

2014

Modern Pathology

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“…Although some authors (8,11,13) tried to relate the congenital and acquired types of smooth muscle hamartoma, it is still preferable to consider the congenital form a separate and distinct clinicopathologic entity (8,(14)(15)(16). The lesion is usually apparent at birth and is probably not as rare as it was initially thought.…”

Section: Discussionmentioning

confidence: 99%

Congenital Smooth Muscle Hamartoma of the Skin

Gagné

1993

Pediatric Dermatology

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A 2-month-old white girl had a congenital, tan-colored, slightly elevated, 3 x 2-cm plaque on the left midback. Clinically, the lesion was suspected to be a solitary mastocytoma. Rubbing the lesion produced a transient erythema and edema that was similar to Darier sign seen in mastocytoma. Analysis of a skin biopsy specimen revealed a smooth muscle hamartoma; special stains did not show evidence of increased numbers of mast cells. This relatively uncommon condition can be confused with a variety of other cutaneous diseases. Light microscopic examination of a skin biopsy specimen establishes the diagnosis. A review of the approximately 50 cases reported in the literature showed that there is no known associated systemic involvement or malignant transformation. The clinical lesions usually become less prominent with time.

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“…It is usually congenital, but may also arise later in life. In humans, it usually takes the form of a congenital skin lesion presenting as an indurated macular or plaque lesion, typically on the trunk, extremity or mammary region 1,2 . Histologically, it is characterized by the presence of numerous well-defined, randomly oriented, thick bundles of smooth muscle fibres scattered throughout the dermis, sometimes extending into the subcutaneous tissue 3,4 .…”

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confidence: 99%

“…In the skin, hamartomas may occur in the epidermis, skin appendages, dermis and/or subcutaneous tissue 1 . Cutaneous smooth muscle hamartomas have been infrequently described in humans and dogs.…”

mentioning

confidence: 99%

“…Until now, in all the cases of congenital smooth muscle hamartoma described, the lesion has developed from the arrector pili muscles [1][2][3][4] , whereas in the cases with acquired smooth muscle hamartoma, lesions have been reported to originate from either the arrector pili or dartoic muscles 5,6 . In animals, on the other hand, there is no classification into congenital and acquired hamartomas.…”

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confidence: 99%

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Smooth Muscle Hamartoma of the Nipple in a Beagle Dog

et al. 2007

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Abstract:A smooth muscle hamartoma of the nipple was found in a 9-month-old beagle dog. No abnormalities were observed on necropsy. Histopathologically, there was a solitary lesion measuring 3 × 1 mm in size in the dermis of the nipple. The lesion was unencapsulated but well demarcated and was composed of numerous intersecting fascicles, with the nuclei of the some of the cells being round or oval-shaped, and those of others being fusiform with blunt edges. These fascicles, associated with the nipple smooth muscle, were surrounded by a large amount of mature collagen. There was no evidence of cytologic atypia or mitotic figures. Immunohistochemistry showed positive staining for alpha-smooth muscle actin (αSMA), but negative staining for S-100 protein, cytokeratin and p63, suggesting that the lesion was derived from the smooth muscle of the nipple. Therefore, a diagnosis of smooth muscle hamartoma of the nipple was made. (J Toxicol Pathol 2007; 20: 175-177)

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Congenital arrector pili hamartoma. A case report and review of the spectrum of Becker's melanosis and pilar smooth-muscle hamartoma

Cited by 39 publications

References 13 publications

Smooth muscle tumors of soft tissue and non-uterine viscera: biology and prognosis

Smooth muscle tumors of soft tissue and non-uterine viscera: biology and prognosis

Congenital Smooth Muscle Hamartoma of the Skin

Smooth Muscle Hamartoma of the Nipple in a Beagle Dog

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