Congenital anomalies of the kidney and the urinary tract: A murmansk county birth registry study

Postoev, Vitaly Alexandrovich; Grjibovski, Andrej M.; Kovalenko, Anton Alexandrovich; Anda, Erik Eik; Nieboer, Evert; Odland, Jon Øyvind

doi:10.1002/bdra.23475

Cited by 31 publications

(40 citation statements)

References 36 publications

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“…There is a potential that PAR is much higher, given that the RR for the association between any diabetes type in the mother and CAKUT is estimated to be at least 50% higher and the prevalence of women with any diabetes at pregnancy will automatically be higher than the prevalence of gestational diabetes only. Fourteen studies 5,[24][25][26][27][28][29]33,35,37,41,[44][45][46] that compare CAKUT in offspring of mothers with any diabetes type and CAKUT in mothers with no diabetes are summarized here. The summary measure of association is RR, 1.51 (95% confidence interval [CI], 1.36-1.67).…”

Section: Discussionmentioning

confidence: 99%

“…30 There were 2 population-based case-control studies that included all newborns with CAKUT from the population, and the frequency of mothers with and without diabetes was calculated among children with CAKUT. 32,33 Because these were population based, these 2 studies were included in the meta-analysis. The total number of cases was 17,013 across 13 case-control studies.…”

Section: Assessment Of Included Studiesmentioning

confidence: 99%

“…45 These were accounted for in studies with larger study populations. Figure 3 5,[24][25][26][27][28][29]33,35,37,41,[44][45][46] shows the relative risk (RR) and 95% CIs from the combination of cohort studies and case-control studies investigating the relationship among all diabetes during pregnancy and CAKUT and their pooled random-effects estimates. The estimated values indicate an increased risk of CAKUT associated with any form of diabetes in pregnancy (i.e., pre-existing diabetes or/and gestational diabetes).…”

Section: Qualitative Assessment Of All Included Studiesmentioning

confidence: 99%

“…Forest plot of relative risk (RR) of congenital abnormalities of the kidney and the urinary tract (CAKUT) among (a) gestational diabetes and (b) pre-existing diabetes. Fourteen studies 5,[24][25][26][27][28][29][30][31][32][33][34][35][36][37] that compare CAKUT in offspring of mothers with gestational diabetes (a) and 17 studies 5,13,15,38,[40][41][42][43][44][45][46] of mothers with pre-existing diabetes (b), to CAKUT in mothers with no diabetes are summarized here. This study supports the pathophysiology of CAKUT in the context of hyperglycaemia studied in animal models, which suggests that maternal hyperglycaemia adversely effects kidney development of the fetus.…”

Section: Clinical Researchmentioning

confidence: 99%

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A Systematic Review and Meta-Analysis of Diabetes During Pregnancy and Congenital Genitourinary Abnormalities

Parimi

Nitsch

2020

Kidney International Reports

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Introduction: This study aimed to assess available epidemiological evidence of the relationship between diabetes during pregnancy and congenital abnormalities of the kidney and the urinary tract (CAKUT). Methods: POPLINE, MEDLINE, EMBASE, Global Health, CINAHL, and Cochrane Library were searched to retrieve 6962 articles of which 15 case-control and 11 cohort studies met the inclusion criteria. Randomeffects meta-analysis was performed to estimate the association between CAKUT and diabetes during pregnancy. Results: Offspring born to mothers with any form of diabetes in pregnancy had a 50% increased risk of CAKUT compared with offspring of mothers without diabetes (relative risk [RR], 1.51; 95% confidence interval [CI], 1.36-1.67). Compared with offspring with nondiabetic mothers, offspring of mothers with preexisting diabetes had an almost 2-fold rate of CAKUT (RR, 1.97; 95% CI, 1.52-2.54). Offspring of mothers with gestational diabetes had a 39% increased risk of CAKUT (RR, 1.39; 95% CI, 1.26-1.55) compared with offspring of mothers with no diabetes. The subset of studies that adjusted for body mass index (BMI) before pregnancy showed similar associations. Population attributable risks for gestational diabetes were estimated to be 3.7% of cases of CAKUT in the United States, 4% of CAKUT cases in the United Kingdom, with up to 14.4% CAKUT cases in the South Asian population in the United Kingdom. Conclusion: This study suggests that 2.0% to 3.7% of cases of CAKUT in the United States, and up to 14% of CAKUT in some populations could be eliminated if gestational diabetes was prevented or eliminated.

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Section: Discussionmentioning

confidence: 99%

Section: Assessment Of Included Studiesmentioning

confidence: 99%

Section: Qualitative Assessment Of All Included Studiesmentioning

confidence: 99%

Section: Clinical Researchmentioning

confidence: 99%

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A Systematic Review and Meta-Analysis of Diabetes During Pregnancy and Congenital Genitourinary Abnormalities

Parimi

Nitsch

2020

Kidney International Reports

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“…To determine the sensitivity of our findings to our design/analytic assumptions, we performed several sensitivity analyses. For our examination of the distribution of bladder health, these were: (1) exclusion of women with known bladder conditions (i.e., current LUTS medications, previous incontinence or bladder surgery, chronic indwelling catheterization, and bladder cancer), as their exact position on the LUTS/interference distribution was assumed, not known based on their untreated LUTS/interference; and women with nonbladder conditions that might contribute to LUTS or interference (i.e., genitourinary cancers besides bladder cancer, prolapse of the uterus, bladder, or rectum, congenital urinary tract abnormalities (a large proportion of which are renal 24,25 ), endometriosis, pelvic inflammatory disease, chronic pelvic pain, vulvodynia, and diabetes); and (2) exclusion of nocturia and nighttime interference from the list of LUTS and interference activities, respectively, as these might be caused by nonbladder-related conditions.…”

Section: Statistical Analysesmentioning

confidence: 99%

The Spectrum of Bladder Health: The Relationship Between Lower Urinary Tract Symptoms and Interference with Activities

Sutcliffe¹,

Bavendam

Cain

et al. 2019

Journal of Women's Health

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Background: Little research to date has focused on lower urinary tract symptom (LUTS) prevention and bladder health promotion in women. To address this gap, the Prevention of LUTS Research Consortium developed the following working bladder health definition: ''A complete state of physical, mental, and social well-being related to bladder function [that] permits daily activities [and] allows optimal well-being.'' To begin to inform and quantify this definition, we used data from the Boston Area Community Health Survey, drawing upon its rare collection of information on LUTS and LUTS-specific interference with activities. Methods: At baseline, participants reported their frequency of 15 LUTS and interference with 7 activities. Prevalence ratios (PRs) were calculated by generalized linear models with robust variance estimation, adjusting for LUTS risk factors and individual LUTS. Results: Of the 3169 eligible participants, 17.5% reported no LUTS or interference, whereas the remaining 82.5% reported some frequency of LUTS/interference: 15.1% rarely; 21.7% a few times; 22.6% fairly often/usually; and 22.9% almost always. LUTS independently associated with interference were urgency incontinence, any incontinence, urgency, nocturia, perceived frequency, and urinating again after <2 hours (PRs = 1.2-1.5, all p < 0.05). Conclusions: Our findings suggest that bladder health exists on a continuum, with approximately one in five women considered to have optimal bladder health (no LUTS/interference), the majority to have intermediate health (LUTS/interference rarely to usually), and a further one in five to have worse or poor health (LUTS/ interference almost always). These findings underscore the need for LUTS prevention and bladder health promotion.

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Association of prenatal renal ultrasound abnormalities with pathogenic copy number variants in a large Chinese cohort

Qin

et al. 2022

Ultrasound in Obstet & Gyne

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Objectives To assess the clinical utility of prenatal chromosomal microarray analysis (CMA) in fetuses with abnormal renal sonographic findings, and to evaluate the association of pathogenic or likely pathogenic copy number variants (P/LP CNVs) with different types of renal abnormality. Methods This was a retrospective study of fetuses at 14–36 weeks screened routinely for renal and other structural abnormalities at the Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region. We retrieved and analyzed data from fetuses with abnormal renal sonographic findings, examined between January 2013 and November 2019, which underwent CMA analysis using tissue obtained from chorionic villus sampling (CVS), amniocentesis or cordocentesis. We evaluated the CMA findings according to type of renal ultrasound anomaly and according to whether renal anomalies were isolated or non‐isolated. Results Ten types of renal anomaly were reported on prenatal ultrasound screening, at a mean ± SD gestational age of 24.9 ± 4.8 weeks. The anomalies were diagnosed relatively late in this series, as 64% of cases with an isolated renal anomaly underwent cordocentesis rather than CVS. Fetal pyelectasis was the most common renal ultrasound finding, affecting around one‐third (34.32%, 301/877) of fetuses with a renal anomaly, but only 3.65% (n = 11) of these harbored a P/LP CNV (comprising: isolated cases, 2.37% (4/169); non‐isolated cases, 5.30% (7/132)). Hyperechogenic kidney was found in 5.47% (n = 48) of fetuses with a renal anomaly, of which 39.58% (n = 19) had a P/LP CNV finding (comprising: isolated cases, 44.44% (16/36); non‐isolated cases, 25.00% (3/12)), the highest diagnostic yield among the different types of renal anomaly. Renal agenesis, which accounted for 9.92% (n = 87) of all abnormal renal cases, had a CMA diagnostic yield of 12.64% (n = 11) (comprising: isolated cases, 11.54% (9/78); non‐isolated cases, 22.22% (2/9); unilateral cases, 11.39% (9/79); bilateral cases, 25.00% (2/8)), while multicystic dysplastic kidney (n = 110), renal cyst (n = 34), renal dysplasia (n = 27), crossed fused renal ectopia (n = 31), hydronephrosis (n = 98), renal duplication (n = 42) and ectopic kidney (n = 99) had overall diagnostic rates of 11.82%, 11.76%, 7.41%, 6.45%, 6.12%, 4.76% and 3.03%, respectively. Compared with the combined group of CMA‐negative fetuses with any other type of renal anomaly, the rate of infant being alive and well at birth was significantly higher in CMA‐negative fetuses with isolated fetal pyelectasis or ectopic kidney, whereas the rate was significantly lower in fetuses with isolated renal agenesis, multicystic dysplastic kidney or severe hydronephrosis. The most common pathogenic CNV was 17q12 deletion, which accounted for 30.14% (22/73) of all positive CMA findings, with a rate of 2.51% (22/877) among fetuses with an abnormal renal finding. Fetuses with 17q12 deletion exhibited a wide range of renal phenotypes. Other P/LP CNVs in the recurrent region that were associated with prenatal renal ultraso...

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Congenital anomalies of the kidney and the urinary tract: A murmansk county birth registry study

Abstract: Background

Cited by 31 publications

References 36 publications

A Systematic Review and Meta-Analysis of Diabetes During Pregnancy and Congenital Genitourinary Abnormalities

A Systematic Review and Meta-Analysis of Diabetes During Pregnancy and Congenital Genitourinary Abnormalities

The Spectrum of Bladder Health: The Relationship Between Lower Urinary Tract Symptoms and Interference with Activities

Association of prenatal renal ultrasound abnormalities with pathogenic copy number variants in a large Chinese cohort

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