Congenital Anomalies of Renal Tubules in a Case of "Infantile Nephrosis"

Fetterman, George H.

doi:10.1001/archpedi.1960.04020040321004

Cited by 28 publications

(6 citation statements)

References 7 publications

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“…Only three previous cases have been recorded (Fetterman and Feldman, 1960;Torres, 1962;Roy, Bedard, Bonenfant, and Fortin, 1964). A fourth case has been reported in an 18-month-old child (Feinerman, Burke, and Bahn, 1957).…”

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confidence: 98%

Congenital nephrotic syndrome and renal vein thrombosis in infancy

Alexander

Campbell

1971

J Clin Pathol

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Three of the four cases of the nephrotic syndrome in infancy described show the typical clinical and pathological features of the commonly termed congenital nephrotic syndrome, and two of them abnormal immunoglobulins. Two of the infants were siblings. The placental abnormalities and renal electron microscopic changes are reported and are believed to be involved in antigen-antibody reactions. The literature is reviewed and the possible aetiology of these lesions is discussed. The fourth case is considered to be due to thrombosis of the inferior vena cava and renal veins, an extremely rare cause of the nephrotic syndrome in infants.

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confidence: 98%

Congenital nephrotic syndrome and renal vein thrombosis in infancy

Alexander

Campbell

1971

J Clin Pathol

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“…The capillary loops, in contradistinction, are not entirely consistent with fetal glomeruli. FETTER-MAN and FELDMAN [6] have brieflydescribed the electron microscope picture of two normal biopsy specimens taken from infants 28 days of age who were operated upon for surgical correction of congenital hypertrophic pyloric stenosis and who had no evidence of renal disease. They described an increase in the number of epithelial cells with little cytoplasm and a paucity of cytoplasmic organelles, in comparison with the findings in adult glomeruli.…”

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confidence: 99%

Nephrogenic Diabetes Insipidus A Study of the Fine Structure of the Kidney in a Seven-Month-Old Male

Abelson

1968

Pediatr Res

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This is the first description of the fine structure of the kidney in nephrogenic diabetes insipidus. Striking changes were found throughout the entire kidney. In both proximal and distal tubules, mitochondria contained concentric ringed structures, and many mitochondria had myelin figures associated with their outer membranes as seen in figures 6-13. In figure 9, the intramitochondrial body is seen to be deforming the outer mitochondrial membrane, and in figure 7, it is shown to be continuous with this membrane. Gristae were virtually absent in the areas where the concentric ringed structures are found. There was a disruption of the mitochundrial architecture with formation of the ringed bodies which may be the precursors of the myelin figures. In addition to the tubular changes, the glomerular ultrastructure had a predominately fetal configuration which would seem to be unusual in a seven-month-old infant. SpeculationThe alteration in mitochondrial membranes should be correlated with enzymatic studies in this and other tubular disorders. It might then be ascertained whether these mitochondrial changes can be related to the decrease in content of 3' -5' cyclic AMP.

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“…As yet relatively little precise information is available, though some microdissection studies have already been made on cystic kidneys by Greene (1922), Bialestock (1956Bialestock ( , 1960, Paatela (1961), and Osathanondh and Potter (1964), and ofcysts associated with infantile nephrosis or microcystic renal disease by Oliver (1960), Giles, Pugh, Darmady, Stranack, and Woolf (1957), Fetterman and Feldman (1960), and Paatela (1961Paatela ( , 1963. These cysts show a wide variety of forms in regard to size, shape, and relation to the tubules which, in a group of reasonably comparable examples, can be recognized as being stages in the evolution of the larger (presumably older), well-developed forms.…”

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Cysts arising in the renal tubules. A microdissection study.

Baxter¹

1965

Archives of Disease in Childhood

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Congenital Anomalies of Renal Tubules in a Case of "Infantile Nephrosis"

Cited by 28 publications

References 7 publications

Congenital nephrotic syndrome and renal vein thrombosis in infancy

Congenital nephrotic syndrome and renal vein thrombosis in infancy

Nephrogenic Diabetes Insipidus A Study of the Fine Structure of the Kidney in a Seven-Month-Old Male

Cysts arising in the renal tubules. A microdissection study.

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