Congenital anomalies

Parikh, Aditi; Wiesner, Georgia L.

doi:10.1016/b978-0-323-06545-0.00038-8

Cited by 2 publications

(1 citation statement)

References 42 publications

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“…(3, 28–30) While rates of anomalies for infants with T13 or T18 are well-documented, not all anomalies impact survival equally. (11, 12, 29, 31) For example, infants with limb anomalies may not require immediate inpatient care, whereas infants with ductal-dependent cardiac lesions require immediate decisions about surgical intervention.…”

Section: Introductionmentioning

confidence: 99%

Major anomalies and birth-weight influence NICU interventions and mortality in infants with trisomy 13 or 18

et al. 2017

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Objective to describe neonatal intensive care unit (NICU) medical interventions and NICU mortality by birth weight and major anomaly types for infants with trisomy 13 (T13) or 18 (T18). Study Design retrospective cohort analysis of infants with T13 or T18 from 2005–12 in the Pediatrix Medical Group. We classified infants into 3 groups by associated anomaly type: neonatal surgical, non-neonatal surgical, and minor. Outcomes were NICU medical interventions and mortality. Results 841 infants were included from 186 NICUs. NICU mortality varied widely by anomaly type and birth weight, from 70% of infants <1500g with neonatal surgical anomalies to 31% of infants ≥2500g with minor anomalies. Infants ≥1500g without a neonatal surgical anomaly comprised 66% of infants admitted to the NICU; they had the lowest rates of NICU medical interventions and NICU mortality. Conclusions Risk stratification by anomaly type and birth weight may help provide more accurate family counseling for infants with T13 and T18.

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