“…It is of importance to present the correlation between the number of the minor anomalies and the risk for presence of major anomaly found in different sources of information: if the individual doesn't have any minor anomaly, the probability of existence of major anomaly is about 1.4%; one minor malformation carries a probability for major anomaly of 3%; if two minor malformations are present in the same person, the probability of existing major anomaly is about 11-15%, and if three or more minor anomalies are present, the probability of major anomaly, especially chromosomal abnormality, raises over 50% [22,23]. Less than 1% of newborns have three or more anomalies, and these newborns are at higher than 20% risk for a major malformation [24,25]. Another source of information presents that children who have two minor anomalies have a 10% risk of developing major anomalies, finally, those children with 3 or more minor anomalies have again a 20% risk of developing a major anomaly [26].…”