Congenital anomalies among live births in a polluted area. A ten-year retrospective study

Gianicolo, Emilio Antonio Luca; Bruni, Antonella; Rosati, Enrico; Sabina, Saverio; Guarino, Roberto; Padolecchia, G.; Leo, Carlo Giacomo; Vigotti, Maria Angela; Andreassi, Maria Grazia; Latini, Giuseppe

doi:10.1186/1471-2393-12-165

Cited by 19 publications

(9 citation statements)

References 28 publications

(24 reference statements)

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“…Kve mothers was similar to that in the general population (30,31,32). Among the neonates born to TRAb Cve mothers, two had unusual cardiac abnormalities, both mothers having required ATD therapy during pregnancy.…”

Section: Discussionmentioning

confidence: 51%

“…Cve /ATD Cve group, three patients had severe cardiac abnormalities (30,31,32) namely, tetralogy of Fallot (mother given L-T 4 after surgery during all pregnancy and neonate with normal thyroid function), left ventricular hypertrophy with pericardial detachment (mother started on propylthiouracil during the second trimester for hyperthyroidism and neonate with normal thyroid function but hyperkinesis on day 1), and ventricular dysfunction (mother given propylthiouracil during the second trimester for hyperthyroidism and neonate diagnosed with hyperthyroidism on day 3). Figure 1 shows the thyroid function of the 33 neonates born to mothers positive for TRAb.…”

Section: Clinical Description Of the Newborns At Birthmentioning

confidence: 99%

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Management of neonates born to women with Graves' disease: a cohort study

Besançon

Beltrand

Gac

et al. 2014

European Journal of Endocrinology

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Objective: Hyperthyroidism in neonates born to mothers with Graves' disease (GD) can be associated with significant morbidity and mortality, but is still overlooked by clinicians. Management of neonatal hyperthyroidism would be improved by a better understanding of the predictive factors involved. The aim of this study was to evaluate the course of thyroid function and clinical outcomes during the first postnatal month in babies born to mothers with GD. Design: Prospective observational study. Methods: Sixty-eight neonates born to mothers with GD were managed from birth and divided into three groups based on thyrotropin receptor antibody (TRAb) and anti-thyroid drug (ATD) status in the mother: TRAb /ATDCve neonates, 24 (72.7%) had positive TRAb on cord blood assays, and seven of these developed neonatal hyperthyroidism. FT 4 elevation between days 3 and 7 but not at birth was predictive of the development of hyperthyroidism. Conclusions: TRAb status should be checked in the third trimester in mothers with GD and on cord blood in their neonates; if positive, it indicates a high risk of neonatal hyperthyroidism. FT 4 measurement at birth should be repeated between days 3 and 5 (and by day 7 at the latest); rapid FT 4 elevation during the first postnatal week is predictive of hyperthyroidism and warrants ATD therapy.

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Section: Discussionmentioning

confidence: 51%

Section: Clinical Description Of the Newborns At Birthmentioning

confidence: 99%

Management of neonates born to women with Graves' disease: a cohort study

Besançon

Beltrand

Gac

et al. 2014

European Journal of Endocrinology

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“…Recently, most studies have focused on the identification of risk factors of NSCL/P. Many epidemiological studies have confirmed that maternal age [10–12], maternal educational level [2, 13], family income [13, 14], abnormal reproductive histories [15], family history [14–16], history of infection during pregnancy [17], medication use during pregnancy [18, 19], ambient environment pollution [20], parental occupational hazards exposure [21–23], maternal nutrient intake [23–26], and maternal lifestyle factors (alcohol drinking, smoking) [27–29] are associated with NSCL/P. However, an individual risk prediction tool for NSCL/P has not been reported.…”

Section: Introductionmentioning

confidence: 99%

A discriminant analysis prediction model of non-syndromic cleft lip with or without cleft palate based on risk factors

Luo

et al. 2016

BMC Pregnancy Childbirth

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BackgroundA risk prediction model of non-syndromic cleft lip with or without cleft palate (NSCL/P) was established by a discriminant analysis to predict the individual risk of NSCL/P in pregnant women.MethodsA hospital-based case–control study was conducted with 113 cases of NSCL/P and 226 controls without NSCL/P. The cases and the controls were obtained from 52 birth defects’ surveillance hospitals in Hunan Province, China. A questionnaire was administered in person to collect the variables relevant to NSCL/P by face to face interviews. Logistic regression models were used to analyze the influencing factors of NSCL/P, and a stepwise Fisher discriminant analysis was subsequently used to construct the prediction model.ResultsIn the univariate analysis, 13 influencing factors were related to NSCL/P, of which the following 8 influencing factors as predictors determined the discriminant prediction model: family income, maternal occupational hazards exposure, premarital medical examination, housing renovation, milk/soymilk intake in the first trimester of pregnancy, paternal occupational hazards exposure, paternal strong tea drinking, and family history of NSCL/P. The model had statistical significance (lambda = 0.772, chi-square = 86.044, df = 8, P < 0.001). Self-verification showed that 83.8 % of the participants were correctly predicted to be NSCL/P cases or controls with a sensitivity of 74.3 % and a specificity of 88.5 %. The area under the receiver operating characteristic curve (AUC) was 0.846.ConclusionsThe prediction model that was established using the risk factors of NSCL/P can be useful for predicting the risk of NSCL/P. Further research is needed to improve the model, and confirm the validity and reliability of the model.

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“…This could be causative for alterations in many physiological processes and could lead to disease and abnormalities in exposed individuals [ 6 ]. An increased risk of congenital anomalies and perinatal mortality due to maternal exposure during pregnancy in polluted areas has been also documented [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Micro-RNAs: Crossroads between the Exposure to Environmental Particulate Pollution and the Obstructive Pulmonary Disease

Finicelli

Squillaro

Galderisi

et al. 2020

IJMS

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Environmental pollution has reached a global echo and represents a serious problem for human health. Air pollution encompasses a set of hazardous substances, such as particulate matter and heavy metals (e.g., cadmium, lead, and arsenic), and has a strong impact on the environment by affecting groundwater, soil, and air. An adaptive response to environmental cues is essential for human survival, which is associated with the induction of adaptive phenotypes. The epigenetic mechanisms regulating the expression patterns of several genes are promising candidates to provide mechanistic and prognostic insights into this. Micro-RNAs (miRNAs) fulfil these features given their ability to respond to environmental factors and their critical role in determining phenotypes. These molecules are present in extracellular fluids, and their expression patterns are organ-, tissue-, or cell-specific. Moreover, the experimental settings for their quantitative and qualitative analysis are robust, standardized, and inexpensive. In this review, we provide an update on the role of miRNAs as suitable tools for understanding the mechanisms behind the physiopathological response to toxicants and the prognostic value of their expression pattern associable with specific exposures. We look at the mechanistic evidence associable to the role of miRNAs in the processes leading to environmental-induced pulmonary disease (i.e., chronic obstructive pulmonary disease).

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Congenital anomalies among live births in a polluted area. A ten-year retrospective study

Cited by 19 publications

References 28 publications

Management of neonates born to women with Graves' disease: a cohort study

Management of neonates born to women with Graves' disease: a cohort study

A discriminant analysis prediction model of non-syndromic cleft lip with or without cleft palate based on risk factors

Micro-RNAs: Crossroads between the Exposure to Environmental Particulate Pollution and the Obstructive Pulmonary Disease

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