Congenital angiomyoma of the tongue: case report

Yh, Kim; Yw, Jang; H, Pai; Kim, Seong‐Gon

doi:10.1259/dmfr/32524441

Cited by 7 publications

(12 citation statements)

References 9 publications

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“…Most of the AL are diagnosed between the fourth and sixth decade of life [ 38 , 39 ], even if several studies have documented the tumor occurrence in subjects from 1 month to 84 years old [ 9 ]. There is only one study that reported a congenital tumor [ 21 ]. When AL occurs in this population, it is called leiomyomatous epulis, which clinically mimics a congenital granular cell tumor [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical and Immunohistochemical Features of Oral Angioleiomyoma: A Comprehensive Review of the Literature and Report of a Case in a Young Patient

Giudice

Bennardo

Buffone

et al. 2019

Case Reports in Dentistry

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Angioleiomyoma (AL) is an uncommon benign soft tissue neoplasia arising from the tunica media of the smooth muscle cells. AL appears as a solitary and slow-growing mass and seldom is observed in oral tissues. We reported a rare case of AL involving the cheek of a 17-year-old young woman. A review of the English-language literature was performed entering the keywords “angioleiomyoma” and “oral” in the search fields of PubMed. 70 results were identified. Excluded were cases that were not in the oral cavity or not compatible with the AL diagnosis or report lacking immunohistochemical analysis. According to the exclusion criteria, we selected 30 studies that included 63 cases of AL. The results of the review showed an average age of 42.97 years with a prevalence between the fourth and fifth decade of life with a male-to-female ratio of 1.95 : 1. The most affected sites were palate, buccal mucosa of the cheek, lip, tongue, and gingiva. Surgical excision was the treatment of choice, and diagnosis was possible through histopathological and immunohistochemical analysis. SMA, vimentin, CD34, desmin, and S-100 were the most common markers to guide the histopathological diagnosis of oral AL. In conclusion, oral AL is a rare entity, especially in adolescence as in the reported case of AL of the cheek in a 17-year-old woman. The clinical aspects of AL did not allow clinicians to make a correct presumptive diagnosis. A scrupulous histopathological analysis and immunohistochemical examinations are fundamental to differentiate AL from other lesions.

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Section: Discussionmentioning

confidence: 99%

Clinical and Immunohistochemical Features of Oral Angioleiomyoma: A Comprehensive Review of the Literature and Report of a Case in a Young Patient

Giudice

Bennardo

Buffone

et al. 2019

Case Reports in Dentistry

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“…The present cohort was significantly younger than those investigated in other studies, with a mean age of 42.5 years at diagnosis and a peak in presentation in the fourth to sixth decades. Angioleiomyomas are particularly rare in children ( 1 , 3 , 11 – 14 ) and there is only one study of a congenital tumor ( 15 ). In the present study, the youngest patient was 10 years old, with an angioleiomyoma located in the mandible.…”

Section: Discussionmentioning

confidence: 99%

Angioleiomyomas in the head and neck: A retrospective clinical and immunohistochemical analysis

Liu

et al. 2014

Oncology Letters

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Angioleiomyoma is a benign soft-tissue tumor originating from vascular smooth muscle, and is rare in the head and neck. The present study retrospectively examined a cohort of patients with head and neck angioleiomyoma treated at the West China Hospital of Stomatology, and also subjected archived tissues to modern immunohistochemical analysis. In total, 21 patients were treated for angioleiomyoma between 1978 and 2012 at the West China Hospital of Stomatology, Sichuan University (Chengdu, Sichuan, China). Medical records were examined and paraffin block sections were cut and stained with hematoxylin and eosin, Masson’s trichrome stain and Van Gieson stain, prior to being subjected to immunohistochemical analysis to re-evaluate and confirm the diagnoses. Angioleiomyomas were found to account for only 0.18% of the benign head and neck tumors in the patients presenting to the hospital over the past 34 years. The diagnosis was more common in males (male:female ratio, 1.625:1) and the mean age at diagnosis was 42.5 years. The most common sites were the buccal mucosa, parotid gland and palate. More than half of the tumors (61.9%) were >2 cm in diameter. Five tumors presented with pain and/or tenderness. The histological subtype was reported as solid in five cases, venous in six, cavernous in nine and venous-cavernous in one. Three tumors exhibited nerve neurofibrils. All tumors were excised with no subsequent recurrence. Cytological and imaging examinations were not useful for pre-operative diagnosis. Angioleiomyoma is a benign tumor that causes limited morbidity. Surgical excision is the only effective treatment and recurrence is rare. The present study revealed that nerves were present in a small proportion (14.3%) of tumors. It was hypothesized that the compression of nerves accompanying numerous blood vessels in the tumor may cause pain, particularly in venous- and cavernous-type angioleiomyomas.

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“…It is sometimes difficult to differentiate an angioleiomyoma from other spindle-cell tumors. Several oral tumors should be included in the histopathological differential diagnosis (16) , namely schwannomas, neurofibromas, fibromatoses, hemangiopericytomas, hemangioendotheliomas, well-diferentiated leiomyosarcomas, fibrosarcomas, inflammatory myofibroblastic tumors, and malignant schwannomas (11) . To that end, immunohistochemistry is a valuable, precise, and reliable method for establishing a definitive diagnosis (14,15) .…”

Section: Discussionmentioning

confidence: 99%

Oral angioleiomyoma: a case report and considerations on differential diagnosis

Barboza¹,

Ginani²,

Leite-Segundo³

et al. 2013

J. Bras. Patol. Med. Lab.

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Angioleiomyomas are benign mesenchymal tumors derived from smooth muscle, which rarely occur in the oral cavity. We report a case of an angioleiomyoma occurring in the maxillary gingiva. The lesion was painless, with a lobulated surface, fibrous in consistency, and firm upon palpation. Microscopic examination showed an encapsulated tumor mass composed of large vascular channels of varying calibers, surrounded by thick walls of irregularly arranged, spindle-shaped cells, which were immunopositive for smooth-muscle actin. It is sometimes difficult to differentiate an angioleiomyoma from other spindle-cell tumors, thus we emphasize its histological differential diagnosis.

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Congenital angiomyoma of the tongue: case report

Cited by 7 publications

References 9 publications

Clinical and Immunohistochemical Features of Oral Angioleiomyoma: A Comprehensive Review of the Literature and Report of a Case in a Young Patient

Clinical and Immunohistochemical Features of Oral Angioleiomyoma: A Comprehensive Review of the Literature and Report of a Case in a Young Patient

Angioleiomyomas in the head and neck: A retrospective clinical and immunohistochemical analysis

Oral angioleiomyoma: a case report and considerations on differential diagnosis

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