Congenital and infantile melanoma: Review of the literature and report of an uncommon variant, pigment-synthesizing melanoma

Richardson, Stephen K.; Tannous, Zeina; Mihm, Martín C.

doi:10.1067/mjd.2002.120602

Cited by 120 publications

(92 citation statements)

References 53 publications

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“…ATM has been reported almost equally in men and women, with ages ranging from 0 to 92 years [5,31,33,35,36]. Interestingly, cases in children are present in all studies.…”

Section: Discussion and Reviewmentioning

confidence: 58%

“…The morphological parallel between such lesions and a similar process in humans was first reported by Darier in 1925 [27], who chose the term melanosarcoma. Since then, only 58 case studies of ATM in humans have been published under the names ATM, melanophagic melanoma or pigment-synthesizing melanoma [5,28,29,30,31,32,33,34,35,36,37,38,39,40]. In the first published series, pathological features comprised confluent dermal sheets of heavily pigmented cells whose nuclei, where discernible, were large and in some cases described as moderately atypical, with one prominent nucleolus [33].…”

Section: Discussion and Reviewmentioning

confidence: 99%

“…The limited experience with these lesions suggests that PEM is best considered as a low-grade melanocytic tumor with limited metastatic potential [2]. Thus far, pigmented melanocytic proliferations with epithelioid cells consistent with PEM have very rarely been described as congenital, and no histopathological prognostic criteria have been found [1,3,4,5]. Four-color fluorescent in situ hybridization (FISH) for melanocytic lesions has recently been developed as a new tool to assess the malignancy of difficult melanocytic lesions [6,7].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Two Congenital Cases of Pigmented Epithelioid Melanocytoma Studied by Fluorescent in situ Hybridization for Melanocytic Tumors: Case Reports and Review of These Recent Topics

Battistella

Prochazkova-Carlotti

Berrebi³

et al. 2010

Dermatology

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The term ‘pigmented epithelioid melanocytoma’ (PEM) has recently been proposed as a nosological framework grouping lesions formerly known as animal-type melanomas, sporadic epithelioid blue nevi and Carney complex-associated epithelioid blue nevi. Congenital PEMs have been reported extremely rarely and their prognosis is poorly known. Four-color fluorescent in situ hybridization (FISH) for melanocytic lesions is a recent method developed to assess the malignant potential of ambiguous melanocytic lesions. Here we describe 2 cases of congenital epithelioid and strongly pigmented melanocytic lesions consistent with PEM. No BRAF gene mutation was found in the 2 cases. FISH for melanocytic lesions was also performed. The first case proved entirely negative, whereas the second one showed a positive zone with an extra copy of chromosome 6. The prognosis and management of PEM are discussed, with a review of the available data on the history, demographics, molecular alterations and histopathological aspects of this entity. PEM seems to represent a unique low-grade melanocytic tumor with a limited potential of metastasis to lymph nodes, but a favorable long-term clinical course. The published data about FISH for melanocytic tumors, and especially PEM, are reviewed. Four-color FISH may be a useful tool to assess more accurately the prognosis of these tumors.

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“…ATM has been reported almost equally in men and women, with ages ranging from 0 to 92 years [5,31,33,35,36]. Interestingly, cases in children are present in all studies.…”

Section: Discussion and Reviewmentioning

confidence: 58%

Section: Discussion and Reviewmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Two Congenital Cases of Pigmented Epithelioid Melanocytoma Studied by Fluorescent in situ Hybridization for Melanocytic Tumors: Case Reports and Review of These Recent Topics

Battistella

Prochazkova-Carlotti

Berrebi³

et al. 2010

Dermatology

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“…Three patients were newborns, according to Richardson's classification 13 and they had congenital melanoma. All these cases developed in giant congenital nevus (Figure 4-5).…”

Section: Childhood Melanomamentioning

confidence: 99%

“…The precise incidence and prognosis of childhood malignant melanomas are not known although there are increasing numbers of literature data about this subject in the recent years [9][10][11][12][13][14][15][16][17][18][19] .…”

Section: Childhood Melanomamentioning

confidence: 99%

Histopathological aspects of unusual skin tumors with clinical correlations

Varga

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Pigment-Synthesizing Melanocytic Neoplasm With Protein Kinase C Alpha (PRKCA) Fusion

Bahrami

Lee

et al. 2016

JAMA Dermatol

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Congenital and infantile melanoma: Review of the literature and report of an uncommon variant, pigment-synthesizing melanoma

Cited by 120 publications

References 53 publications

Two Congenital Cases of Pigmented Epithelioid Melanocytoma Studied by Fluorescent in situ Hybridization for Melanocytic Tumors: Case Reports and Review of These Recent Topics

Two Congenital Cases of Pigmented Epithelioid Melanocytoma Studied by Fluorescent in situ Hybridization for Melanocytic Tumors: Case Reports and Review of These Recent Topics

Histopathological aspects of unusual skin tumors with clinical correlations

Pigment-Synthesizing Melanocytic Neoplasm With Protein Kinase C Alpha (PRKCA) Fusion

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