Congenital and infantile beriberi

Gelder, David W. Van; Darby, Frances U.

doi:10.1016/s0022-3476(44)80158-5

Cited by 14 publications

(1 citation statement)

References 12 publications

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“…Global child health recurrent laryngeal nerve caused by compression from dilated pulmonary artery or by direct involvement . 14 The historical perspective of infantile beriberi is presented in table 2. The largest numbers of infantile beriberi were described from Philippines during the period from 1906 to 1930, 1954-1958 and again in 2007.…”

Section: Original Researchmentioning

confidence: 99%

Thiamine-responsive acute severe pulmonary hypertension in exclusively breastfeeding infants: a prospective observational study

et al. 2020

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ObjectivesSevere pulmonary hypertension (PH) causing right heart failure can occur due to thiamine deficiency in exclusively breastfeeding infants. This study describes the clinical profile and management of thiamine-responsive acute pulmonary hypertension.MethodsA prospective observational study of infants presenting with severe PH without any other significant heart or lung disease. History of symptoms, clinical examination, echocardiography and basic investigations were performed. Dietary patterns of mothers were recorded. Thiamine was administered and serial echocardiography was performed.ResultsA total of 250 infants had severe PH and 231 infants responded to thiamine. The mean age was 3.2±1.2 months. Fast breathing, poor feeding, vomiting and aphonia were the main symptoms. Tachypnoea, tachycardia and hepatomegaly were found on examination. Echocardiogram revealed grossly dilated right heart with severe PH. Intravenous thiamine was administered to all the babies based on clinical suspicion. Clinical improvement with complete resolution of PH was noticed within 24–48 hours. Babies were followed up to a maximum of 60 months with no recurrence of PH. All the mothers consumed polished rice and followed postpartum food restriction.ConclusionThiamine deficiency is still prevalent in selected parts of India. It can cause life-threatening PH in exclusively breastfeeding infants of mothers who are on a restricted diet predominantly consisting of polished rice. It can contribute to infant mortality. Thiamine administration based on clinical suspicion leads to remarkable recovery. High degree of awareness and thiamine supplementation in relevant geographical areas is required to tackle this fatal disease.

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Section: Original Researchmentioning

confidence: 99%