Congenital Alveolar Rhabdomyosarcoma Presenting as a Blueberry Muffin Baby

Abstract

Congenital alveolar rhabdomyosarcoma in a newborn was reported. She had multiple subcutaneous tumors and looked like a blueberry muffin baby. From the clinical signs and the histological pictures, a diagnosis of neuroblastoma was considered. Laboratory data showed no abnormalities. Electron microscopic examination revealed myofilament and incipient stria formation. On the basis of these data, a final diagnosis of congenital alveolar rhabdomyosarcoma associated with multiple skin metastases was made.

Manifestation of alveolar rhabdomyosarcoma as primary cutaneous lesions in a neonate with Beckwith-Wiedemann syndrome

“…On the other hand, 19 cases of neonatal alveolar RMS without BWS have been reported [12][13][14][15][16][17][18][19]. The patients were predominantly female infants, and the most common sites were the extremities.…”

“…In particular, neonates with skin lesions had a poorer prognosis than those without lesions. Therefore, we should consider the possibility of malignant neoplastic disease when diagnosing the neonatal skin lesions that present as a plaque-like or nodular lesion with slow but progressive growth [13][14][15].…”

Fetomaternal haemorrhage and prenatal intracranial bleeding: two more causes of blueberry muffin baby

“…Dierential diagnosis of blueberry mun lesions includes neoplastic in®ltrative disease such as metastasis of neuroblastoma (stage IV-S) or congenital alveolar rhabdomyosarcoma, congenital leukaemia and congenital histiocytosis (Letterer-Siwe disease, self-healing reticulohistiocytosis) [5,7,9,10,11,13]. These diseases typically present with more nodular and in®ltrated lesions [3].…”

Blueberry-Muffin-Baby

“…fetofetaler Transfusion (sog. Bei Blueberry-Muffin-Läsionen, welchen neoplastische Infiltrationen zugrunde liegen, sind es (sub)kutane Infiltrate von kongenitalen Leukämien [9,18], Langerhans-Zellen-Histiozytosen [11], des kongenitalen Neuroblastoms [20] und alveolären Rhabdomyosarkoms [14] (Tabelle 2). Bei Blueberry-Muffin-Läsionen, welchen neoplastische Infiltrationen zugrunde liegen, sind es (sub)kutane Infiltrate von kongenitalen Leukämien [9,18], Langerhans-Zellen-Histiozytosen [11], des kongenitalen Neuroblastoms [20] und alveolären Rhabdomyosarkoms [14] (Tabelle 2).…”

“…Subkutane Metastasen können Blueberry-Muffin-Läsionen ähnlich sein [14]. Subkutane Metastasen können Blueberry-Muffin-Läsionen ähnlich sein [14].…”