Congenital absence of the bilateral internal carotid artery: a review of the associated (ab)normalities from a newborn status to the eighth decade of life

Vasović, Ljiljana; Trandafilović, Milena; Vlajković, Slobodan; Radenković, Goran

doi:10.1007/s00381-017-3629-1

Cited by 13 publications

(7 citation statements)

References 64 publications

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“…Furthermore, in our previous study we have demonstrated that the marked alteration of the glomerular filtration rate and of the proximal tubule reabsorption observed in the ZDF rats was prevented by oral administration of RLE, and we hypothesized that these events were correlated with its action on ROS productions [22]. In fact, in agreement with other research [39][40][41], in which the antioxidant protective effect on the diabetic nephropathy progression was demonstrated, we found that RLE restored the antioxidant pathways, in particular SOD, CAT, and GPx activities.…”

Section: Discussionsupporting

confidence: 89%

Effects of a Red Orange and Lemon Extract in Obese Diabetic Zucker Rats: Role of Nicotinamide Adenine Dinucleotide Phosphate Oxidase

Damiano

Lauritano

Longobardi

et al. 2020

JCM

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Diabetic nephropathy (DN) is the primary cause of end-stage renal disease, worldwide, and oxidative stress has been recognized as a key factor in the pathogenesis and progression of DN. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase has the most important contribution to reactive oxygen species generation during the development of DN. Bioactive compound use has emerged as a potential approach to reduce chronic renal failure. Therefore, a red orange and lemon extract (RLE) rich in anthocyanins was chosen in our study, to reduce the toxic renal effects during the development of DN in Zucker diabetic fatty rat (ZDF). RLE effects were examined daily for 24 weeks, through gavage, in ZDF rats treated with RLE (90 mg/kg). At the end of the experiment, ZDF rats treated with RLE showed a reduction of the diabetes-associated up-regulation of both NOX4 and the p47-phox and p22-phox subunits, and restored the BAX/BCL-2 ratio respect to ZDF rats. Furthermore, RLE was able to reduce the oxidative DNA damage measured in urine samples in ZDF rats. This study showed that RLE could prevent the renal damage induced by DN through its capacity to inhibit NOX4 and apoptosis mechanisms.

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Section: Discussionsupporting

confidence: 89%

Effects of a Red Orange and Lemon Extract in Obese Diabetic Zucker Rats: Role of Nicotinamide Adenine Dinucleotide Phosphate Oxidase

Damiano

Lauritano

Longobardi

et al. 2020

JCM

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“…Congenital absence of ICA is a rare entity and occurs in less than 0.01% of the population [ 5 , 6 ]. Bilateral absence of arteries is about 10% [ 7 ] and has been identified in 60 cases in the reviewed literature [ 8 ]. The absence may be related to agenesis or aplasia ICA [ 9 – 11 ]; however, agenesis indicates the complete failure of vessel formation and absence of carotid canal into the embryo what was the case of “our patient”.…”

Section: Discussionmentioning

confidence: 99%

Stroke in sickle cell disease in association with bilateral absence of the internal carotid arteries. Case report

Marković

Milenković²,

Jocić-Jakubi

et al. 2022

BMC Neurol

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Background Congenital absence of the internal carotid artery (ICA) is a highly infrequent congenital incidence and occurs in less than 0.01% of the population; bilateral absence is exceedingly rare, diagnosed below 10% of the unilateral absence of the ICA. Sickle cell disease (SCD) is a serious disorder and carries a high risk of stroke. Case presentation We present a five-year-old child with SCD who experienced an ischemic stroke episode with epileptic seizures. Neuroimaging revealed the agenesis of both ICAs. The frequency, embryology, and collateral pathway of the vascular anomaly as the clinical presentation, of this rare hematologic disease, are discussed. Conclusions Sickle cell disease (SCD) carries a high risk of stroke. Congenital absence of ICA occurs in less than 0.01% of the population; bilateral absence is diagnosed below 10% of the unilateral absence of the ICA.

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“…Although a headache was more common among them, it was also an initial symptom in other cases of vascular absence, such as the uni-or bilateral absence of the VA [92], or the bilateral absence of the ICA [93], as well as in many pathological disorders. A suspect pulsatile swelling in the neck caused by the cervical aortic arch, as a reason of/for the discovery of the CCA aplasia [6, 9, 33, 34, 36, 39, 67, 70, 73-75, 77, 81], may not always be related to it, as evidenced by Shepherd et al [37].…”

Section: Collateral Pathwaysmentioning

confidence: 99%

“…ere was no associated pathology in 17.80% of cases; however, there were 21 different pathological states in other cases, and among them the aneurysms of some cerebral arteries in 13.69% [24,31,42,52,53,58,61,62,67,71]. e authors have presented the morphofunctional status of blood vessels and stated the clinical importance in the cases of the absence of the VA [92], or the bilateral ICA [93], and the CCA in this manuscript; the next task will be a comparison of the cases with the le and the ones with the right ICA absence.…”

Section: Collateral Pathwaysmentioning

confidence: 99%

Congenital Aplasia of the Common Carotid Artery: A Comprehensive Review

Vasović

Trandafilović

Vlajković

2019

BioMed Research International

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In an attempt to describe the morphofunctional consequences of uni- and bilateral aplasia of the common carotid artery (CCA), which is usually a vascular source of the external carotid (ECA) and internal carotid (ICA) arteries, we investigated online databases of anatomical and clinical papers published from the 18th century to the present day. We found 87 recorded cases of uni- and bilateral CCA aplasia in subjects from the first hours to the eighth decade of life, which had been discovered in 14 (known) countries. Four crucial parameters were described: the embryology of the carotid arteries, morphophysiology of the carotid arteries, CCA aplasia, and unilateral versus bilateral CCA aplasia, including history, general data, diagnosing, vascular sources, caliber, course of the separated ECA and ICA, associated vascular variants, and pathological disorders. To complete the knowledge of the morphofunctional consequences of the absence of some artery of the carotid system, and risking the possibility of repeating some words, as “carotid artery”, or “carotid aplasia” and the headings from our previous article about bilateral ICA absence, this review is the first in the literature that recorded all cases of the CCA aplasia published and/or cited for the past 233 years. Main characteristic of the CCA absence is its association with 21 different diseases, among which the aneurysms were in 13.69% of cases, and 17.80% of cases were without pathology.

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Congenital absence of the bilateral internal carotid artery: a review of the associated (ab)normalities from a newborn status to the eighth decade of life

Abstract: This review noted all the cases of the bilateral ICA aplasia published for the past 104 years. Although there were 11.6% of cases of the associated cerebral aneurysms and 1-4 cases of 16 other diseases, approximately one quarter of the cases was without any pathology.

Cited by 13 publications

References 64 publications

Effects of a Red Orange and Lemon Extract in Obese Diabetic Zucker Rats: Role of Nicotinamide Adenine Dinucleotide Phosphate Oxidase

Effects of a Red Orange and Lemon Extract in Obese Diabetic Zucker Rats: Role of Nicotinamide Adenine Dinucleotide Phosphate Oxidase

Stroke in sickle cell disease in association with bilateral absence of the internal carotid arteries. Case report

Congenital Aplasia of the Common Carotid Artery: A Comprehensive Review

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