Congenital abnormalities in calves associated with Peaton virus infection in Japan

Matsumori, Yoichi; Aizawa, Maki; Sakai, Yoshiko; Inoue, Daisuke; Kodani, Michiko; Tsuha, Osamu; Beppu, Akira; Hirashima, Yoshimasa; Kono, R; Ohtani, Akira; Yanase, Tohru; Shirafuji, Hiroaki; Kato, Tomoko; Tanaka, Shogo; Yamakawa, Makoto

doi:10.1177/1040638718796269

Cited by 14 publications

(10 citation statements)

References 37 publications

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“…The reported cases that were probably affected by PEAV, SATV, or SHAV were highly sporadic after their epizootic in Japan. The congenital lesions in the brains of calves infected with PEAV or SHAV were milder than those of calves infected with AKAV or AINOV (157,166). It is probable that the viruses currently circulating in East Asia have relatively low pathogenicity.…”

Section: Other Orthobunyavirusesmentioning

confidence: 98%

“…Australian researchers reported that the experimental infection of a pregnant ewe with PEAV induced congenital defects in its lamb (156). Precolostral sera obtained from 31 malformed calves between 1996 and 2016 were positive for PEAV, but negative for known teratogenic viruses (157). These findings suggested that, like AKAV and AINOV, PEAV causes congenital malformations in calves and lambs.…”

Section: Other Orthobunyavirusesmentioning

confidence: 99%

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Endemic and Emerging Arboviruses in Domestic Ruminants in East Asia

2020

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Epizootic congenital abnormalities caused by Akabane, Aino, and Chuzan viruses have damaged the reproduction of domestic ruminants in East Asia for many years. In the past, large outbreaks of febrile illness related to bovine ephemeral fever and Ibaraki viruses severely affected the cattle industry in that region. In recent years, vaccines against these viruses have reduced the occurrence of diseases, although the viruses are still circulating and have occasionally caused sporadic and small-scaled epidemics. Over a long-term monitoring period, many arboviruses other than the above-mentioned viruses have been isolated from cattle and Culicoides biting midges in Japan. Several novel arboviruses that may infect ruminants (e.g., mosquito-and tick-borne arboviruses) were recently reported in mainland China based on extensive surveillance. It is noteworthy that some are suspected of being associated with cattle diseases. Malformed calves exposed to an intrauterine infection with orthobunyaviruses (e.g., Peaton and Shamonda viruses) have been observed. Epizootic hemorrhagic disease virus serotype 6 caused a sudden outbreak of hemorrhagic disease in cattle in Japan. Unfortunately, the pathogenicity of many other viruses in ruminants has been uncertain, although these viruses potentially affect livestock production. As global transportation grows, the risk of an accidental incursion of arboviruses is likely to increase in previously non-endemic areas. Global warming will also certainly affect the distribution and active period of vectors, and thus the range of virus spreads will expand to higher-latitude regions. To prevent anticipated damages to the livestock industry, the monitoring system for arboviral circulation and incursion should be strengthened; moreover, the sharing of information and preventive strategies will be essential in East Asia.

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Section: Other Orthobunyavirusesmentioning

confidence: 98%

Section: Other Orthobunyavirusesmentioning

confidence: 99%

Endemic and Emerging Arboviruses in Domestic Ruminants in East Asia

2020

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“…From 1972 to 1975, a serious outbreak of Akabane disease in Japan caused more than 31,000 cases of abortion, stillbirth and congenital arthrogryposis and hydranencephaly (12). Recently, Peaton virus and Shamonda virus have also been associated with congenital abnormalities in ruminants in Japan and Israel (13)(14)(15). Natural genome segment reassortment has been shown to contribute significantly to the evolution of orthobunyaviruses, occurring between different viruses and between variants of the same virus type (16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Seroepidemiology of Aino Virus in Farmed and Free-Ranging Cervids in the Republic of Korea

Yeh

2021

Front. Vet. Sci.

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Aino virus is an infectious, non-contagious, vector-borne agent that has been implicated in arthrogryposis-hydranencephaly syndrome in newborn cattle, sheep, and goats. Information about reservoirs and host animal species susceptible to Aino virus remains unclear. To further explore the role of cervids in Aino virus infection transmission, we investigated cervid sera to determine the prevalence of Aino virus-neutralizing antibodies and to identify factors correlated with antibody positivity. We screened cervid serum samples collected in the Republic of Korea to better understand infection patterns in this animal species. Overall, Aino virus infection was widespread; 75 of 716 (10.5%, 95% [95% CI] = 8.4–13.4) farmed-cervid serum samples collected from 292 herds contained antibodies to Aino virus. Serological evidence of Aino virus infection was demonstrated in 5 of 43 free-ranging cervids, accounting for a prevalence rate of ~11.6% (95% CI = 4.6–26.4). Our results revealed that age class and geographic location affected seroprevalence. The main risk factors associated with Aino virus seroprevalence were older age (> 2 years old, OR = 2.221, 95% CI = 1.209–4.079, P = 0.009 in adults), southern provinces (OR = 2.432, 95% CI = 1.445–4.093, P = 0.001), and western provinces (OR = 1.905, 95% CI = 1.041–3.488, P = 0.034). The results in this study suggest that cervid species might serve as important hosts for the transmission of Aino virus, highlighting the need for careful monitoring of Aino virus infections in cervids.

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“…The most widespread orthobunyavirus of the Simbu serogroup affecting ruminants is Akabane virus (AKAV), which is endemic to Africa, the Middle East, Asia, and Australia [ 13 , 14 ]. Additional Simbu serogroup orthobunyaviruses of veterinary importance include Schmallenberg virus (SBV), Aino virus, Peaton virus, and Shamonda virus [ 15 , 16 , 17 , 18 ]. Examples of orthobunyaviruses pathogenic to humans include La Crosse virus, a major cause of encephalitis in children in the U.S., Oropouche virus, which generally causes a febrile illness, and Ngari virus, associated with hemorrhagic fever [ 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Shuni Virus Replicates at the Maternal-Fetal Interface of the Ovine and Human Placenta

et al. 2020

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Shuni virus (SHUV) is a neglected teratogenic and neurotropic orthobunyavirus that was discovered in the 1960s in Nigeria and was subsequently detected in South Africa, Zimbabwe, and Israel. The virus was isolated from field-collected biting midges and mosquitoes and shown to disseminate efficiently in laboratory-reared biting midges, suggesting that members of the families Culicidae and Ceratopogonidae may function as vectors. SHUV infections have been associated with severe neurological disease in horses, a variety of wildlife species, and domesticated ruminants. SHUV infection of ruminants is additionally associated with abortion, stillbirth, and congenital malformations. The detection of antibodies in human sera also suggests that the virus may have zoonotic potential. To understand how SHUV crosses the ruminant placenta, we here infected pregnant ewes and subsequently performed detailed clinical- and histopathological examination of placental tissue. We found that SHUV targets both maternal epithelial cells and fetal trophoblasts, that together form the maternal-fetal interface of the ovine placenta. Experiments with human placental explants, furthermore, revealed replication of SHUV in syncytiotrophoblasts, which are generally highly resistant to virus infections. Our findings provide novel insights into vertical transmission of SHUV in sheep and call for research on the potential risk of SHUV infection during human pregnancies.

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Congenital abnormalities in calves associated with Peaton virus infection in Japan

Cited by 14 publications

References 37 publications

Endemic and Emerging Arboviruses in Domestic Ruminants in East Asia

Endemic and Emerging Arboviruses in Domestic Ruminants in East Asia

Seroepidemiology of Aino Virus in Farmed and Free-Ranging Cervids in the Republic of Korea

Shuni Virus Replicates at the Maternal-Fetal Interface of the Ovine and Human Placenta

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