Congenital Abnormalities and the Pathologist

Seller, Mary J.; Bobrow, Martin

doi:10.1007/978-1-4471-3523-4_5

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…However, the causes of CFL are still unknown. There are some suggestions that external as well as internal congenital anomalies of the female reproductive tract may be the result of enzymatic defects or prenatal drug exposure (13) and consumption of certain types of synthetic steroids in early pregnancy (14). In the presented case, the birth of a healthy calf from a heifer with CFL might support the hypothesis that this defect was inherited recessively, as previously emphasized by Isachenko et al (7) in common marmosets.…”

Section: Resultssupporting

confidence: 77%

The treatment of congenitally developed fused vulva labia in a Brown-Swiss heifer

Selçuk¹

2014

Turk J Vet Anim Sci

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A series of 3-[(4-substitutedpiperazin-1-yl)methyl]-1H -indole derivatives were synthesized, and their structures were confirmed by spectral analysis. All the compounds were tested for their cytotoxic activity in vitro against 3 human tumor cell lines: human liver (HUH7), breast (MCF7), and colon (HCT116). Among the designed derivatives, most of the compounds showed significant cytotoxicity against liver and colon cancer cell lines with lower IC 50 concentrations than the standard drug 5-fluorouracil. Compound 3s, with 3,4-dichlorophenyl substituent on the piperazine ring, was the most active in suppressing the growth of all screened cancer cells.

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Section: Resultssupporting

confidence: 77%

The treatment of congenitally developed fused vulva labia in a Brown-Swiss heifer

Selçuk¹

2014

Turk J Vet Anim Sci

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“…The causes of congenitally fused labia are still unknown but genetic, environmental or a combination of both is considered as most common causative factors of congenital defects. However, enzymatic defects or prenatal drug exposure (Craighill, 1993) and consumption of certain types of synthetic steroids in early pregnancy (Seller and Bobrow, 1987) are the forerunners of external and internal congenital anomalies of the female reproductive tract. Thus in the present study it was concluded that the heifer was suffering from congenitally developed fused labia without any reproductive abnormality with normal estrous behaviour and normal genital tract on per rectal examination.…”

Section: Treatments and Discussionmentioning

confidence: 99%

Surgical Correction of Congenitally Fused Vulva Labia in A Cross Bred Heifer

Pandey¹,

Kumar²,

Sharma³

et al. 2018

Int.J.Curr.Microbiol.App.Sci

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“…In addition, external as well as internal congenital anomalies of the female reproductive tract were reported to be the result of enzymatic defects or prenatal drug exposure [5]. In humans, irregular development of the external genitalia has also been caused by the consumption of certain types of synthetic steroids in early pregnancy [29].…”

Section: Discussionmentioning

confidence: 99%

Congenitally caused fused labia in the common marmoset (Callithrix jacchus)

Isachenko

Nayudu

Isachenko

et al. 2002

J of Medical Primatology

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In this paper, the occurrence of an external genital abnormality in female marmoset monkeys (fused labia) is discussed. This malformation was detected, for the first time, in a group of animals at the German Primate Center (GPC), Goettingen. The malformed vulva was completely sealed except for an opening of 1.5-2.5 mm around the urethra sufficient for urination. Because of this defect the animals were not able to copulate. As a consequence, the affected females were functionally infertile although they had a normal genital tract and a regular cycle. This vulvar abnormality was found in 12 females, offspring of 10 pairs in which either one or both came to the German Primate Center from two genetically related colonies in Munich, Germany, and one colony in Basel, Switzerland. The abnormality appeared to be recessive and inheritable from either parent. In pairs in which both animals were from one of the mentioned colonies, 45% of the female offspring were affected. In pairs where only one partner came from these colonies, 26% of female offspring had the malformation. These results indicate that avoidance of inbreeding, which is frequently performed in primate colonies, may reduce, but not eliminate the expression of abnormalities of genetic origin. Therefore selective breeding is required, and, in colonies where these recessive mutations are widespread, the development of genetic screening tests would be advantageous.

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Congenital Abnormalities and the Pathologist

Cited by 4 publications

References 14 publications

The treatment of congenitally developed fused vulva labia in a Brown-Swiss heifer

The treatment of congenitally developed fused vulva labia in a Brown-Swiss heifer

Surgical Correction of Congenitally Fused Vulva Labia in A Cross Bred Heifer

Congenitally caused fused labia in the common marmoset (Callithrix jacchus)

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