Confusion Assessment Method (CAM) Indicators When CAM Positivity in 647 Individuals Has Good Outcome

Delirium: a synthesis of current knowledge

“…We demonstrated that confusion assessment method (CAM) positive delirium in 647 acute geriatric admissions had no effect on survival in hospital or at 30, 90, 180 or 365 days post admission. 2 Subsequent articles on the Central Coast Australia Delirium Intervention Study (CADIS; ClinicalTrials.gov NCT01650896) showed that a 25% decline in attention, executive function or memory in 24 hours produced a more robust phenotype than the CAM with respect to eliminating false positives, such as BPSD and Parkinson's disease psychosis, and generating high reversibility. 3,4 The phenotype of delirium is to asthma what dementia is to the chronic obstructive pulmonary disease (COPD) phenotype.…”

“…We believe the meta-analysis of Witlox has the highest level of evidence on survival and delirium, and we expect delirium researchers of the included studies would have been able to discriminate well between BPSD and delirium. 2 The confusion assessment method (CAM) is not the 'gold standard' test for delirium. The more strict the defi nition of delirium (according to DSM criteria), the stronger the association with mortality can be expected.…”

Diagnosis of delirium in older people

“…In our prospectiverandomised controlled trial, Clinical Trials.gov NCT01650896 Central Coast Australia Delirium Intervention Study, the 5‐Digit Span Forward reverses most quickly followed by the 6‐Digit Span Forward and delirium index. New psychotic features are often the slowest components to reverse (Regal, ). Distinguishing behavioural and psychological symptoms of dementia from delirium depends greatly on full reports from family and informants (Regal, ).…”

Improving the logic and rigour of delirium trials

“…I am the principal investigator in Central Coast Australia Delirium Intervention Study (CADIS). 4 This is a prospective randomised controlled trial registered with Clinical Trials.Gov NCT01650896 and Australian New Zealand Clinical Trials Registry 362750. CADIS compares CAM+ and CAM− subjects as well as subjects positive and negative by two new diagnostic criteria: change in instrumental activities of daily living and rapid high-amplitude critical cognitive decline.…”