Conformational Tuning Shapes the Balance between Functional Promiscuity and Specialization in ParalogousPlasmodiumAcyl-CoA Binding Proteins
Rahul Dani,
Westley Pawloski,
Dhruv Kumar Chaurasiya
et al.
Abstract:Paralogous proteins confer enhanced fitness to organisms via complex sequence-conformation codes that shape functional divergence, specialization, or promiscuity. Here, we resolve the underlying mechanism of promiscuous binding versus partial sub-functionalization in paralogs by studying structurally-identical Acyl-CoA Binding Proteins (ACBPs) from Plasmodium falciparum that serve as promising drug targets due to their high expression during the protozoan proliferative phase. Combining spectroscopic measuremen… Show more
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