Conformational stability, vibrational (FT-IR and FT-Raman) spectra and computational analysis of m-trifluoromethyl benzoic acid

Balachandran, V.; Karpagam, V.; Santhi, G.; Revathi, B.; Ilango, G. Saravana; Kavimani, M.

doi:10.1016/j.saa.2014.08.086

Cited by 15 publications

(3 citation statements)

References 37 publications

(37 reference statements)

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“…The rocking deformation of C–H and Si–C bond stretching were observed at 843 and 790 cm –1 , respectively (Figure a). The symmetric stretching of the –CF 3 groups in the analyzed diazirines was seen in the 1140 cm –1 region . The diazirine ring was expected to be observed near 1630 cm –1 , but this band was weak in control molecule 5 (Figure b) .…”

Section: Resultsmentioning

confidence: 90%

“…The symmetric stretching of the −CF 3 groups in the analyzed diazirines was seen in the 1140 cm −1 region. 64 The diazirine ring was expected to be observed near 1630 cm −1 , but this band was weak in control molecule 5 (Figure 5b). 65 The peak at 1631 cm −1 was related to N�N, while the peaks at 1610 and 1344 cm −1 were assigned to the C−N bond.…”

Section: Surface Characterizationmentioning

confidence: 95%

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Functionalization of Polydimethylsiloxane with Diazirine-Based Linkers for Covalent Protein Immobilization

Li,

Bi,

Musolino

et al. 2023

ACS Appl. Mater. Interfaces

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Biomolecule attachment to solid supports is critical for biomedical devices, such as biosensors and implants. Polydimethylsiloxane (PDMS) is commonly used for these applications due to its advantageous properties. To enhance the biomolecule immobilization on PDMS, a novel technique is demonstrated using newly synthesized diazirine molecules for the surface modification of PDMS. This nondestructive process involves a reaction between diazirine molecules and PDMS through C−H insertion with thermal or ultraviolet activation. The success of the PDMS modification is confirmed by various surface characterization techniques. Bovine serum albumin (BSA) and immunoglobulin G (IgG) are strongly attached to the modified PDMS surfaces, and the amount of protein is quantified using iodine-125 radiolabeling. The results demonstrate that PDMS is rapidly functionalized, and the stability of the immobilized proteins is significantly improved with multiple types of diazirine molecules and activation methods. Confocal microscopy provides three-dimensional images of the distribution of immobilized IgG on the surfaces and the penetration of diazirine-based linkers through the PDMS substrate during the coating process. Overall, this study presents a promising new approach for functionalizing PDMS surfaces to enhance biomolecule immobilization, and its potential applications can extend to multimaterial modifications for various diagnostic and medical applications such as microfluidic devices and immunoassays with relevant bioactive proteins.

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Section: Resultsmentioning

confidence: 90%

Section: Surface Characterizationmentioning

confidence: 95%

Functionalization of Polydimethylsiloxane with Diazirine-Based Linkers for Covalent Protein Immobilization

Li,

Bi,

Musolino

et al. 2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…Density of states (DOS) [23] which provides the molecular orbital contribution of different constituting elements to the total system is also calculated by using GaussSum program [24]. Electronic spectrum along with HOMO-LUMO energies [25][26][27][28][29][30] of the title compound has been investigated using Time-dependent (TD-DFT) approach.…”

Section: Methodsmentioning

confidence: 99%

Spectroscopic (FT-IR, 1H, 13C NMR, UV), DOS and orbital overlap population analysis of copper complex of (E)-4-(2-(4-nitrophenyl) diazenyl)-N, N bis ((pyridin-2-yl) methyl) benzamine by density functional theory

Diwaker

2015

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Comparative study on the photocatalytic activity of biomass carbon doped Bi2WO6 crystallite with self-assembled hierarchical structure

Liu

Huang

Cao

et al. 2015

J Mater Sci: Mater Electron

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Conformational stability, vibrational (FT-IR and FT-Raman) spectra and computational analysis of m-trifluoromethyl benzoic acid

Cited by 15 publications

References 37 publications

Functionalization of Polydimethylsiloxane with Diazirine-Based Linkers for Covalent Protein Immobilization

Functionalization of Polydimethylsiloxane with Diazirine-Based Linkers for Covalent Protein Immobilization

Spectroscopic (FT-IR, 1H, 13C NMR, UV), DOS and orbital overlap population analysis of copper complex of (E)-4-(2-(4-nitrophenyl) diazenyl)-N, N bis ((pyridin-2-yl) methyl) benzamine by density functional theory

Comparative study on the photocatalytic activity of biomass carbon doped Bi2WO6 crystallite with self-assembled hierarchical structure

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