“…Supporting this hypothesis, laboratory evidence has shown that disease proteins can travel through local and long-range pathways via transynaptic spread (Frost et al, 2009;Palop and Mucke, 2010;Sanders et al, 2014). Although the relationship between the strength of functional connectivity and underlying white matter integrity is still being examined (Honey et al, 2009;Van Den Heuvel et al, 2009;Hermundstad et al, 2013), the results of our rs-fcMRI analysis are broadly consistent with previously reported patterns of white matter degeneration in svPPA (Acosta-Cabronero et al, 2011;Agosta et al, 2012;Iaccarino et al, 2015).…”