Conformational Control in Metallofoldamers: Design, Synthesis and Structural Properties

Abstract

Metallofoldamers are sequence‐specific oligomers, which are designed to fold into three‐dimensional architectures upon metal coordination. Their folding can involve additional noncovalent interactions and results in new chiral secondary structures, enhanced stabilization of existing secondary structures, or unique materials for specific applications. This microreview highlights recent advances in the field.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

A rationally designed metal-binding helical peptoid for selective recognition processes

“…In recent years, chemists started to explore possibilities to imitate these unique recognition properties, mostly by developing biomimetic foldamers2 capable of binding metal ions 3–5. Peptoids, N -substituted glycine oligomers, are peptidomimetics capable of forming stable helical structures that resemble the polyproline type helices if chiral bulky side groups are incorporated within their backbone 6.…”

The Challenge of Conformational Isomerism in Cyclic Peptoids

“…Further stabilization of oligoamide species was accomplished through formation of sodium metal complexes which shaped new and unexpected host–guest architectures , , …”

Kontrollierte Faltungs‐, Bewegungs‐ und konstitutionelle Dynamik in polyheterocyclischen molekularen Strängen

“…Eine Bandbreite von metallosupramolekularen Architekturen wird durch die Reaktion von polyheterocyclischen Liganden mit Metallionen erhalten, einschließlich der weiten Klasse der Metallo‐Foldamere . Eine spezielle Klasse von Liganden wird durch Stränge gebildet, in denen die Koordinationsuntereinheiten (z.…”