Conformational Characterization of Ipomotaosides and  Their Recognition by COX-1 and 2

Arantes, Pablo Ricardo; Sachett, Liana Guimarães; Graebin, Cedric Stephan; Verli, Hugo

doi:10.3390/molecules19045421

Cited by 5 publications

(2 citation statements)

References 31 publications

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“…Ipomotaoside A ( 40 ) isolated from I. batatas showed remarkable inhibitory activities against COX‐1 and COX‐2 with IC 50 values of 9.3 and 14.5 μM, respectively, while its analog ipomotaoside B ( 41 ) showed lower COX‐1 and COX‐2 inhibitory activities with IC 50 values higher than 100 μM 61 . The docking study between ipomotaoside A ( 40 ) and the COXs suggests a direct interaction between heme group and an acyl chain on both COX‐1 and COX‐2, suggesting that the acyl group is the main responsible for the pharmacological effect of ipomotaoside A ( 40 ) 123 …”

Section: Biological Activitiesmentioning

confidence: 99%

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Chemistry and biological activity of resin glycosides from Convolvulaceae species

Fan

Jiang

et al. 2022

Medicinal Research Reviews

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Carbohydrate-based drug discovery has gained more and more attention during the last few decades. Resin glycoside is a kind of novel and complex glycolipids mainly distributed in plants of the family Convolvulaceae. Over the last decade, a number of natural resin glycosides and derivatives have been isolated and identified, and exhibited a broad spectrum of biological activities, such as cytotoxic, multidrug-resistant reversal on both microbial pathogens and mammalian cancer cells, antivirus, anticonvulsant, antidepressant, sedative, vasorelaxant, laxative, and α-glucosidase inhibitory effects, indicating their potential as lead compounds for drug discovery. A systematic review of the literature studies was carried out to summarize the chemistry and biological activity of resin glycosides from Convolvulaceae species, based on various data sources such as PubMed, Web of Science, Scopus, and Google scholar. The keyword "Convolvulaceae" was paired with "resin glycoside," "glycosidic acid," "glycolipid," or "oligosaccharide," and the references published between 2009 and June 2021 were covered. In this article, we comprehensively reviewed the structures of 288 natural resin glycoside and derivatives newly reported in the last decade. Moreover, we summarized the biological activities and mechanisms of action of the resin

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Section: Biological Activitiesmentioning

confidence: 99%

“…61 The docking study between ipomotaoside A (40) and the COXs suggests a direct interaction between heme group and an acyl chain on both COX-1 and COX-2, suggesting that the acyl group is the main responsible for the pharmacological effect of ipomotaoside A (40). 123…”

Section: Anti-inflammatory Effectsmentioning

confidence: 99%