Conformational Changes Induced by Hapten in Pig Antibodies to the Dinitrophenyl Group. Analysis by Temperature-Perturbation and Solvent-Perturbation Spectroscopy
Abstract:Pig antibodies to the dinitrophenyl group and fragments derived from them by limited proteolysis were studied by temperature-perturbation and solvcnt-perturbation spectroscopy with particular attention to differences between the number of perturbed chromophores in free antibodies and in antibody-hapten complexes.The position of the maxima in the difference spectra show that solvent-perturbed chromophores are exposed to water, but thermally perturbed chromophores are located in a microenvironment the polarity o… Show more
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