2010
DOI: 10.1128/jvi.02371-09
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Conformational Changes in the Capsid of a Calicivirus upon Interaction with Its Functional Receptor

Abstract: Nonenveloped viral capsids are metastable structures that undergo conformational changes during virus entry that lead to interactions of the capsid or capsid fragments with the cell membrane. For members of the Caliciviridae, neither the nature of these structural changes in the capsid nor the factor(s) responsible for inducing these changes is known. Feline junctional adhesion molecule A (fJAM-A) mediates the attachment and infectious viral entry of feline calicivirus (FCV). Here, we show that the infectivity… Show more

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Cited by 63 publications
(93 citation statements)
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References 59 publications
(82 reference statements)
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“…The role of annexin A2 was indicated in cellular entry of the rabbit vesivirus (González-Reyes at al., 2009). Moreover, supporting our hypothesis, recent studies also suggested receptor-induced conformational changes during FCV entry (Ossiboff et al, 2010). Fig.…”
Section: Synthetic Oligosaccharidessupporting
confidence: 76%
“…The role of annexin A2 was indicated in cellular entry of the rabbit vesivirus (González-Reyes at al., 2009). Moreover, supporting our hypothesis, recent studies also suggested receptor-induced conformational changes during FCV entry (Ossiboff et al, 2010). Fig.…”
Section: Synthetic Oligosaccharidessupporting
confidence: 76%
“…High-resolution X-ray structures of several caliciviruses show that the CP three-domain organization (NTA-S-P) is conserved (9,34,37). The NTA are similar and have an important role in capsid assembly; they act as molecular switches that alter subunit interfaces and/or conformations needed to assemble the quasiequivalent Tϭ3 capsid.…”
Section: Discussionmentioning
confidence: 99%
“…X-ray structures of the norovirus Norwalk virus (NV) VLP (37) as well as San Miguel sea lion virus (SMSV) (9) and feline calicivirus (FCV) (34) virions (both vesiviruses) indicate that the virion comprises 90 CP dimers arranged with Tϭ3 symmetry to form 12 pentamers and 20 hexamers. Each monomer has three domains, an N-terminal arm (NTA), a shell (S) composed of an eight-stranded ␤-sandwich, and a flexible protruding domain (P), facilitating virus-host receptor interactions (27,47) at the outermost surface (6).…”
mentioning
confidence: 99%
“…An enzyme-linked immunosorbent assay (ELISA) was performed according to a previous report (38) with minor modifications. In brief, purified DENV-2 NS4A protein was diluted in coating buffer (50 mM carbonate/bicarbonate buffer, pH 9.6) and incubated in 96-well ELISA plates (Nunc) (250 ng/well) at 4°C overnight.…”
Section: Methodsmentioning
confidence: 99%