Conformational changes and location of BSA upon immobilization on zeolitic imidazolate frameworks

Tocco, Davide; Chelazzi, David; Mastrangelo, Rosangela; Casini, Andrea; Salis, Andrea; Fratini, Emiliano; Baglioni, Piero

doi:10.1016/j.jcis.2023.03.107

Cited by 10 publications

(1 citation statement)

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“…The intensity ratio of the D and G bands for the sample is ≈1.54. [ 20 ] The peaks observed at 212 and 273 cm −1 in the Raman spectrum of MIL‐100 and 2‐BSA@Mil‐100 are indeed of particular interest and are associated with vibrational modes within the MOF structure. MIL‐100 contains metal ions coordinated with the carboxylate framework of trimesic acid.…”

Section: Resultsmentioning

confidence: 99%

Hierarchical‐Bioinspired MOFs Enhanced Electromagnetic Wave Absorption

Rehman,

Xu,

et al. 2023

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Proteins exhibit complex and diverse multi‐dimensional structures, along with a wide range of functional groups capable of binding metal ions. By harnessing the unique characteristics of proteins, it is possible to enhance the synthesis of metal‐organic frameworks (MOFs) and modify their morphology. Here, the utilization of biomineralized bovine serum albumin (BSA) protein as a template for synthesizing Mil‐100 with superior microwave absorption (MA) properties is investigated. The multi‐dimensional structure and abundant functional groups of biomineralized BSA protein make it an ideal candidate for guiding the synthesis of Mil‐100 with intricate network structures. The BSA@Mil‐100 synthesized using this method exhibits exceptional uniformity and monodispersity of nanocrystals. The findings suggest that the BSA protein template significantly influences the regulation of nanocrystal and microstructure formation of Mil‐100, resulting in a highly uniform and monodisperse structure. Notably, the synthesized 2‐BSA@Mil‐100 demonstrates a high reflection loss value of −58 dB at 8.85 GHz, along with a maximum effective absorption bandwidth value of 6.79 GHz, spanning from 6.01 to 12.8 GHz. Overall, this study highlights the potential of utilizing BSA protein as a template for MOF synthesis, offering an effective strategy for the design and development of high‐performance MA materials.

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Section: Resultsmentioning

confidence: 99%

Hierarchical‐Bioinspired MOFs Enhanced Electromagnetic Wave Absorption

Rehman,

Xu,

et al. 2023

Small

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Co‐Immobilization of ADH and GDH on Metal–Organic‐Framework: An Effective Biocatalyst for Asymmetric Reduction of Ketones

Ran,

Lin,

et al. 2024

ChemBioChem

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Chiral alcohols are not only important building blocks of various bioactive natural compounds and pharmaceuticals, but can serve as synthetic precursors for other valuable organic chemicals, thus the synthesis of these products is of great importance. Bio‐catalysis represents one effective way to obtain these molecules, however, the weak stability and high cost of enzymes often hinder its broad application. In this work, we designed a biological nanoreactor by embedding alcohol dehydrogenase (ADH) and glucose dehydrogenase (GDH) in metal‐organic‐framework ZIF‐8. The biocatalyst ADH&GDH@ZIF‐8 could be applied to the asymmetric reduction of a series of ketones to give chiral alcohols in high yields (up to 99%) and with excellent enantioselectivities (>99%). In addition, the heterogeneous biocatalyst could be recycled and reused at least four times with slight activity decline. Moreover, E. coli containing ADH and GDH was immobilized by ZIF‐8 to form biocatalyst E. coli@ZIF‐8, which also exhibits good catalytic behaviours. Finally, the chiral alcohols are further converted to marketed drugs (R)‐Fendiline, (S)‐Rivastigmine and NPS R‐568 respectively.

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