Abstract:IDO1
inhibitors have shown promise as immunotherapies for the treatment
of a variety of cancers, including metastatic melanoma and renal cell
carcinoma. We recently reported the identification of several novel
heme-displacing IDO1 inhibitors, including the clinical molecules
linrodostat (BMS-986205) and BMS-986242. Both molecules contain quinolines
that, while being present in successful medicines, are known to be
potentially susceptible to oxidative metabolism. Efforts to swap this
quinoline with an alternati… Show more
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