Conformation–function relationships for the comb-shaped polymer pOEGMA

Liu, Mi; Leroux, Jean‐Christophe; Gauthier, Marc A.

doi:10.1016/j.progpolymsci.2015.03.001

Cited by 59 publications

(60 citation statements)

References 81 publications

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“…32 While these POEGMA polymers were selected because the 950 Da side chains form more hydrophilic blocks than 300 Da OEGMAs, high molecular weight monomers are not as well studied as shorter OEGMA monomers, and their extended side chains may cause considerable steric repulsion between corona-forming blocks, a potentially destabilizing factor. 29,33 …”

Section: Resultsmentioning

confidence: 99%

Zwitterionic Nanocarrier Surface Chemistry Improves siRNA Tumor Delivery and Silencing Activity Relative to Polyethylene Glycol

et al. 2017

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Although siRNA-based nanomedicines hold promise for cancer treatment, conventional siRNA–polymer complex (polyplex) nanocarrier systems have poor pharmacokinetics following intravenous delivery, hindering tumor accumulation. Here, we determined the impact of surface chemistry on the in vivo pharmacokinetics and tumor delivery of siRNA polyplexes. A library of diblock polymers was synthesized, all containing the same pH-responsive, endosomolytic polyplex core-forming block but different corona blocks: 5 kDa (benchmark) and 20 kDa linear polyethylene glycol (PEG), 10 kDa and 20 kDa brush-like poly(oligo ethylene glycol), and 10 kDa and 20 kDa zwitterionic phosphorylcholine-based polymers (PMPC). In vitro, it was found that 20 kDa PEG and 20 kDa PMPC had the highest stability in the presence of salt or heparin and were the most effective at blocking protein adsorption. Following intravenous delivery, 20 kDa PEG and PMPC coronas both extended circulation half-lives 5-fold compared to 5 kDa PEG. However, in mouse orthotopic xenograft tumors, zwitterionic PMPC-based polyplexes showed highest in vivo luciferase silencing (>75% knockdown for 10 days with single IV 1 mg/kg dose) and 3-fold higher average tumor cell uptake than 5 kDa PEG polyplexes (20 kDa PEG polyplexes were only 2-fold higher than 5 kDa PEG). These results show that high molecular weight zwitterionic polyplex coronas significantly enhance siRNA polyplex pharmacokinetics without sacrificing polyplex uptake and bioactivity within tumors when compared to traditional PEG architectures.

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Section: Resultsmentioning

confidence: 99%

Zwitterionic Nanocarrier Surface Chemistry Improves siRNA Tumor Delivery and Silencing Activity Relative to Polyethylene Glycol

et al. 2017

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“…It is likely that the larger number of branches along the polymer backbone may sterically hinder the association of hydrophobic segments on adjacent polymer molecules, necessitating higher polymer concentrations for micelle formation. 53,63 The thermodynamics of micelle formation for each polyurethane were probed using Arrhenius plots, where the ln(X CMC ) of the polymers were plotted as a function of T À1 /K À1 (as shown for 1P30-1h in Fig. 4).…”

Section: Effects Of Polymer Branching On Micellisation Behaviourmentioning

confidence: 99%

“…Indeed, studies have shown that graing increasing numbers of hydrophilic branches onto the hydrophobic backbone of non-thermogelling comb-like amphiphilic copolymers can raise their cloud-point and reduce their ability to form micelles. 53 Therefore, in this manuscript, we explore how different degrees of branching in amphiphilic thermogelling polyurethanes inuence their micellization and subsequent gelation behaviour for the rst time. Firstly, by systematically varying the reaction concentration and duration for polymer synthesis, we generate a library of polyurethanes with different molecular weights and degrees of branching.…”

Section: Introductionmentioning

confidence: 99%

Supramolecular thermogels from branched PCL-containing polyurethanes

et al. 2020

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“…Amphiphilic copolymers containing methoxy oligo(ethylene glycol) methacrylates (MOEGM) have been intensively studied over the last 20 years [ 19 , 20 ]. Biocompatible MOEGM polymers are considered to be drug delivery polymers [ 19 , 20 , 21 , 22 , 23 , 24 ]. The influence of the structure of such copolymers on solution behavior, self-organization, and association have been investigated [ 25 , 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Conformation, Self-Organization and Thermoresponsibility of Polymethacrylate Molecular Brushes with Oligo(ethylene glycol)-block-oligo(propylene glycol) Side Chains

et al. 2021

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Polymethacrylic molecular brushes with oligo(ethylene glycol)-block-oligo(propylene glycol) side chains were investigated by static and dynamic light scattering and viscometry. The solvents used were acetonitrile, tetrahydrofuran, chloroform, and water. The grafted copolymers were molecularly dispersed and dissolved in tetrahydrofuran and acetonitrile. In these solvents, the molar masses of copolymers were determined. In thermodynamically good solvents, namely tetrahydrofuran and acetonitrile, investigated copolymers have a high intramolecular density and the shape of their molecules resembles a star-shaped macromolecule. In chloroform and water, the micelle-like aggregates were formed. Critical micelle concentrations decreased with the lengthening of the hydrophobic block. Molecular brushes demonstrated thermosensitive behavior in aqueous solutions. The phase separation temperatures reduced with an increase in the content of the oligo(propylene glycol) block.

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Conformation–function relationships for the comb-shaped polymer pOEGMA

Cited by 59 publications

References 81 publications

Zwitterionic Nanocarrier Surface Chemistry Improves siRNA Tumor Delivery and Silencing Activity Relative to Polyethylene Glycol

Zwitterionic Nanocarrier Surface Chemistry Improves siRNA Tumor Delivery and Silencing Activity Relative to Polyethylene Glycol

Supramolecular thermogels from branched PCL-containing polyurethanes

Conformation, Self-Organization and Thermoresponsibility of Polymethacrylate Molecular Brushes with Oligo(ethylene glycol)-block-oligo(propylene glycol) Side Chains

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