Conformation-Dependent Sequence Design of Copolymers

Khokhlov, Alexei R.; Иванов, В. А.; Chertovich, Alexander V.; Lazutin, Alexei А.; Khalatur, Pavel G.

doi:10.1007/978-94-010-0401-5_21

Cited by 31 publications

(56 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They were designed based on the simple and well-known fact that the function of all globular proteins depends on two main factors: (i) their globular conformation and (ii) their solubility in aqueous media. The protein-like hydrophobic-polar-sequences were first obtained in computer experiments [79,80]. In globular proteins, the hydrophilic units mainly cover the water exposed surface of the globule, thus supressing interprotein association, whereas hydrophobic units mainly form the core of the globule.…”

Section: Protein-like Copolymersmentioning

confidence: 99%

“…In globular proteins, the hydrophilic units mainly cover the water exposed surface of the globule, thus supressing interprotein association, whereas hydrophobic units mainly form the core of the globule. Amphiphilic copolymers can mimic the behavior of biopolymers and, in certain cases, that of globular proteins [80][81][82][83][84][85][86]. Lozinsky et al prepared N-vinylcaprolactam/N-vinylimidazole copolymers at initial comonomer molar ratios of 85:15 and 90:10 [87].…”

Section: Protein-like Copolymersmentioning

confidence: 99%

See 1 more Smart Citation

Poly(N-vinylcaprolactam), a comprehensive review on a thermoresponsive polymer becoming popular

Cortez-Lemus

Licea‐Claveríe

2016

Progress in Polymer Science

315

327

View full text Add to dashboard Cite

Section: Protein-like Copolymersmentioning

confidence: 99%

Section: Protein-like Copolymersmentioning

confidence: 99%

Poly(N-vinylcaprolactam), a comprehensive review on a thermoresponsive polymer becoming popular

Cortez-Lemus

Licea‐Claveríe

2016

Progress in Polymer Science

315

327

View full text Add to dashboard Cite

“…192 The collapse of linear copolymers into particles presenting regions with different levels of hydrophobicity and hydrophilicity had already been shown when copolymeric units had been used to mimic protein like structures. 202,203 By exposing linear chains of block copolymers to a solvent that is bad for both parts, it is possible to make the chains collapse into spherical objects. The subsequent phase separation taking place between the two different blocks can be exploited to obtain particles with heterogeneous surfaces.…”

Section: Polymer-based Systemsmentioning

confidence: 99%

Limiting the valence: advancements and new perspectives on patchy colloids, soft functionalized nanoparticles and biomolecules

Bianchi

Capone

Coluzza

et al. 2017

Phys. Chem. Chem. Phys.

View full text Add to dashboard Cite

Limited bonding valence, usually accompanied by well-defined directional interactions and selective bonding mechanisms, is nowadays considered among the key ingredients to create complex structures with tailored properties: even though isotropically interacting units already guarantee access to a vast range of functional materials, anisotropic interactions can provide extra instructions to steer the assembly of specific architectures. The anisotropy of effective interactions gives rise to a wealth of self-assembled structures both in the realm of suitably synthesized nano-and micro-sized building blocks and in nature, where the isotropy of interactions is often a zero-th order description of the complicated reality.In this review, we span a vast range of systems characterized by limited bonding valence, from patchy colloids of new generation to polymer-based functionalized nanoparticles, DNA-based systems and proteins, and describe how the interaction patterns of the single building blocks can be designed to tailor the properties of the target final structures.

show abstract

“…[13][14][15][16][17][18] ; a recent review can be found in ref. [19] ). HP copolymers with primary Full Paper: We present a new modification of the socalled conformation-dependent sequence design scheme for HP copolymers which was proposed several years ago (and P refer to the hydrophobic and polar monomer units, respectively).…”

Section: Introductionmentioning

confidence: 99%

Conformation-Dependent Sequence Design of HP Copolymers: An Algorithm Based on Sequential Modifications of Monomer Units

Chertovich

Иванов²,

Zavin

et al. 2002

Macromol. Theory Simul.

Self Cite

View full text Add to dashboard Cite

We present a new modification of the so‐called conformation‐dependent sequence design scheme for HP copolymers which was proposed several years ago (H and P refer to the hydrophobic and polar monomer units, respectively). New method models the real chemical experiments more realistically. We performed Monte Carlo computer simulations using the bond‐fluctuation model for protein‐like copolymers obtained by means of the new “iterative” method and compared the results with those obtained for originally proposed “instantaneous coloring” procedure. Copolymers designed by the “iterative” method are shown to have better‐optimized functional properties. The investigation of the influence of sequence preparation conditions has revealed that the statistical properties of designed HP sequences depend rather strongly on the density of the parent homopolymer globule but not on the composition of H and P units.

show abstract

Conformation-Dependent Sequence Design of Copolymers

Cited by 31 publications

References 33 publications

Poly(N-vinylcaprolactam), a comprehensive review on a thermoresponsive polymer becoming popular

Poly(N-vinylcaprolactam), a comprehensive review on a thermoresponsive polymer becoming popular

Limiting the valence: advancements and new perspectives on patchy colloids, soft functionalized nanoparticles and biomolecules

Conformation-Dependent Sequence Design of HP Copolymers: An Algorithm Based on Sequential Modifications of Monomer Units

Contact Info

Product

Resources

About