Abstract:There is significant interest in the development of antimicrobial
compounds to overcome the increasing bacterial resistance to conventional
antibiotics. Studies have shown that naturally occurring and de novo-designed
antimicrobial peptides could be promising candidates. MSI-594 is a
synthetic linear, cationic peptide that has been reported to exhibit
a broad spectrum of antimicrobial activities. Investigation into how
MSI-594 disrupts the cell membrane is important for better understanding
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