Confocal Mosaicing of Basal Cell Carcinomas in Mohs Micrographic Surgical Skin Excisions

Patel, Yogesh G.; Nehal, Kishwer S.; Halpern, Allan C.; Rajadhyaksha, Milind

doi:10.1364/bio.2006.tui63

Cited by 1 publication

(2 citation statements)

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“…As a noninvasive imaging method, CM is frequently used for the diagnosis of skin cancer (Gerger et al 2008;Mogensen and Jemec 2007;Ulrich et al 2007). Basal and squamous cell carcinomas (Agero et al 2006;Horn et al 2007;Patel et al 2007;Tillman and Carroll 2007), melanocytic nevi and melanomas (Gerger et al 2008;Happe et al 1997;Langley et al 2007;Ono et al 2006;Pellacani et al 2005b), as well as actinic keratoses (Aghassi et al 2000;Ulrich et al 2008), have all been imaged successfully with CM. In melanocytic lesions, the endogenous contrast provided by melanin and melanosomes can allow for the differentiation of benign versus malignant tissues.…”

Section: Confocal Microscopymentioning

confidence: 99%

“…Second, the data collection process is quite fast and can allow for repeated observation of dynamic process in real time. Therefore, CM has been used for longitudinal evaluation of physiological events (Patel et al 2007;Pellacani et al 2005a;Segura et al 2007), disease progression over time (Agero et al 2006;Scope et al 2007), and response to therapy (Astner et al 2008;Paolino et al 2008). On the other hand, there are also many disadvantages associated with CM.…”

Section: Confocal Microscopymentioning

confidence: 99%

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Anatomical and molecular imaging of skin cancer

Hong

Sun²,

Cai

2008

CCID

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Skin cancer is the most common form of cancer types. It is generally divided into two categories: melanoma (∼ 5%) and nonmelanoma (∼ 95%), which can be further categorized into basal cell carcinoma, squamous cell carcinoma, and some rare skin cancer types. Biopsy is still the gold standard for skin cancer evaluation in the clinic. Various anatomical imaging techniques have been used to evaluate different types of skin cancer lesions, including laser scanning confocal microscopy, optical coherence tomography, high-frequency ultrasound, terahertz pulsed imaging, magnetic resonance imaging, and some other recently developed techniques such as photoacoustic microscopy. However, anatomical imaging alone may not be suffi cient in guiding skin cancer diagnosis and therapy. Over the last decade, various molecular imaging techniques (in particular single photon emission computed tomography and positron emission tomography) have been investigated for skin cancer imaging. The pathways or molecular targets that have been studied include glucose metabolism, integrin α v β 3 , melanocortin-1 receptor, high molecular weight melanoma-associated antigen, and several other molecular markers. Preclinical molecular imaging is thriving all over the world, while clinical molecular imaging has not lived up to the expectations because of slow bench-to-bedside translation. It is likely that this situation will change in the near future and molecular imaging will truly play an important role in personalized medicine of melanoma patients.

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