Confocal laser scanning microscopy, optical coherence tomography and transonychial water loss for in vivo investigation of nails

Sattler, Elke; Kaestle, R.; Rothmund, G.; Welzel, Julia

doi:10.1111/j.1365-2133.2011.10730.x

Cited by 44 publications

(70 citation statements)

References 19 publications

(24 reference statements)

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“…Two small OCT studies in HCs described the appearance of the nail using OCT; these mentioned leuconychia with a similar pattern to that which we have noted [22,29]. One other study assessed patients with a variety of nail disorders [30].…”

Section: Discussionmentioning

confidence: 98%

Potential Use of Optical Coherence Tomography and High-Frequency Ultrasound for the Assessment of Nail Disease in Psoriasis and Psoriatic Arthritis

et al. 2013

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Background: Psoriatic nail disease is increasingly recognised to be of major clinical and research relevance. Clinical assessment remains the current gold standard for its evaluation. Objective: We compared optical coherence tomography (OCT) and ultrasound (US) for nail disease assessment in psoriatic disease. Methods: 18 patients with at least one involved nail and 12 healthy controls were scanned using OCT; psoriatic patients also had an US scan (using a linear probe at 9-14 MHz). Nail and contour abnormalities were documented. Clinical onychopathy was scored independently using the modified Nail Psoriasis Severity Index. Results: Among 180 nails, 67.8% had clinical findings whereas 33.9% were abnormal by US and 44.4% had abnormalities on OCT. A positive OCT had a sensitivity and specificity of 44.4 and 95.8%, respectively, with a positive likelihood ratio of 10.7 for nail disease. OCT demonstrated 76.3% absolute agreement compared with clinical assessment and 65% with US. OCT detected subtle abnormalities in 12 clinically normal nails and in 41 nails with normal US findings. Conclusion: These findings show that OCT has a potential for the systematic characterisation of psoriatic nail changes and could be useful in diagnosis and more objective assessment of treatment response.

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Section: Discussionmentioning

confidence: 98%

Potential Use of Optical Coherence Tomography and High-Frequency Ultrasound for the Assessment of Nail Disease in Psoriasis and Psoriatic Arthritis

et al. 2013

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“…The integrity of their borders was also observed using CLSM technique. Exposure to water led to increase in nail thickness along with a transient rise of TOWL [22].…”

Section: Optical Coherence Tomography (Oct)mentioning

confidence: 98%

“…Sattler and co-researchers [22] compared the morphology of healthy nails using two non-invasive techniques, viz. OCT and CLSM (Fig.…”

Section: Optical Coherence Tomography (Oct)mentioning

confidence: 99%

“…Despite providing higher resolution than OCT, CLSM has a number of associated limitations such as the need for experienced examiners, difficulty in positioning and holding the nail during imaging and the necessity for an index matching medium to be applied to the CLSM before measurement [22]. Table II summarizes the operational difference between OCT and CLSM.…”

Section: Confocal Laser Scanning Microscopy (Clsm)mentioning

confidence: 99%

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Structural and component mining of nails using bioengineering techniques

Thatai

Sapra

2016

Intern J of Cosmetic Sci

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The human nail is one of the challenging membranes for the scientists to target and to improve the clinical efficacy of ungual formulations. The understanding of nail physiology, impact of hydration on its properties and presence of trace elements in nails as biomarkers has been explored by various researchers in clinical studies. Despite the importance of biophysical techniques for the assessment of structure and physiology of nail, minimum literature analyses biophysical, biochemical and bioanalytical approaches. However, nowadays scientists in bioengineering field are keen in developing non-invasive, reliable and reproducible techniques for the assessment of different anatomical and functional parameters of nails for testing of ungual products.

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“…Noninvaziv görüntüleme yöntemle-rinden magnetik resonans görüntüleme, optik koherans tomografi, konfokal mikroskopi de dermatolojide kullanılan noninvaziv görüntüle-me yöntemlerindendir. Ancak yukarıda bahsettiğimiz görüntüleme yöntemleri tırnak yapısını ayrıntılı görmemizi sağlasalar da pahalıdır ve kolay ulaşılabilen yöntemler değillerdir (8,9). Çalışmamızda tırnak tutulumu olan ve olmayan psoriazis hastalarında tırnak yatak ve tırnak plak kalınlığı ölçülerek ankilozan spondilit ve kontrol grubunu ile karşılaştırmayı hedeflendi.…”

Section: Introductionunclassified

Tırnak Tutulumu Olan ve Olmayan Psoriazis Hastalarında Tırnak Yatağı ve Tırnak Plağı Kalınlığının Sonografik Olarak Değerlendirilmesi

Rifaioğlu¹,

Üstün²,

Şen³

et al. 2016

Kocatepe Tıp Dergisi

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ÖZAmaç: Psoriazis toplumda %1-3 sıklıkta görülen deri, eklemler ve tırnakları, tutan eritemli skuamlı inflamatuar bir hastalıktır. Psoriazis hastalarında tırnak tutulumu sıklığı %15-% 69 arasında değişmektedir. Ankilozan spondilit ise psoriatik artrit gibi seronegatif spondilartritlerdendir. Ultrasonografi günümüzde yumuşak dokuları değerlendirmek için yaygın kullanılan non invaziv bir görüntüleme yöntemidir.Bu çalışmada tırnak tutulumu olan ve olmayan psoriazis hastalarında tırnak yatak ve tırnak plak kalınlıklarını ultrasonografik olarak ölçerek ankilozan spondilit hastaları ve kontrol grubu ile karşılaştırmayı hedefledik. Gereç ve Yöntem:Otuzyedi psoriazis, 39 ankilozan spondilit hastası ile 33 sağlıklı kontrol çalışmaya dahil edildi. Psoriazis hastaları ile ankilozan spondilit ve kontrol grubunun "tırnak plak kalınlığı" ve "tırnak yatak kalınlığı" hasta oturur pozisyonda ve sağ el masa üzerinde nötral pozisyonda iken gri skala ultrasonografi (LOGIQ5Pre, GE, 4-11-MHz lineer prob) ile aynı hekim tarafından sağ el ikinci parmak tırnağında(indeks tırnak) ölçüldü. Bulgular: Tırnak yatak kalınlıkları psoriazis, ankilozan spondilit ve kontrol grubunda sırasıyla 1.60,1.58,1.51 mm olarak ölçüldü. Tırnak plak kalınlıkları ise psoriazis, ankilozan spondilit ve kontrol grubunda sırasıyla 0.64,0.62,0.68 mm olarak ölçüldü. Psoriazis grubu ile ankilozan spondilit ve kontrol grupları arasında tırnak yatak ve tırnak plak kalınlıkları açısından istatistiksel olarak fark yoktu.(p=0.13,p=0.45)Tırnak yatak kalınlığı, sağ el ikinci parmak tırnağı tutulumu olan hastalarda, olmayanlara göre istatistiksel olarak daha yüksek ölçüldü. (p=0.030) Sonuç: Sonuç olarak çalışmamızda tırnak plak ve tırnak yatak kalınlıkları ultrasonografik olarak değerlendirildiğinde psoriazis grubu ile kontrol grubu ve ankilozan spondilit hastaları arasında fark bulunmadı. Ultrasonografik olarak ölçülen tırnak yatak kalınlıkları sağ el ikinci parmak tırnağı tutulumu olan hastalarda, olmayanlara göre istatistiksel olarak daha yüksekti.Anahtar Kelimeler: Psoriazis; tırnak; ultrasonografi ABSTRACT Objective: Psoriasis is an inflammatory and erythematousscaly disease which involve the skin, joint and nail. It's prevalence is 1-3%. The incidence of nail involvement in psoriasis patient ranged between 15-69 %. Ultrasonography is a noninvasive imaging method widely using for assess the soft tissue image nowadays. In this study we aimed to assess the nail bed and nail plate thickness in psoriasis patient with and without nail involvement and compare with ankylosing spondylitis and control groups. Material and Methods:Thirty-seven patient with psoriasis, 39 patient with ankylosing spondylitis and 33 healthy control were included to the study. Nail bad and nail plate thicknesses was measured with grey scale USG(LOGIQ5Pre, GE, 4-11-MHz lineer prob) from the right hand's second finger(index finger), when the patient seated with the hands in a neutral position over the table.Results: Nail bad thicknesses were measured as 1.60, 1.58, 1.51 mm respectively in psoriasis, an...

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Confocal laser scanning microscopy, optical coherence tomography and transonychial water loss for in vivo investigation of nails

Cited by 44 publications

References 19 publications

Potential Use of Optical Coherence Tomography and High-Frequency Ultrasound for the Assessment of Nail Disease in Psoriasis and Psoriatic Arthritis

Potential Use of Optical Coherence Tomography and High-Frequency Ultrasound for the Assessment of Nail Disease in Psoriasis and Psoriatic Arthritis

Structural and component mining of nails using bioengineering techniques

Tırnak Tutulumu Olan ve Olmayan Psoriazis Hastalarında Tırnak Yatağı ve Tırnak Plağı Kalınlığının Sonografik Olarak Değerlendirilmesi

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