Confocal laser endomicroscopy in breast surgery

Palma, Giovanni D De; Luglio, Gaetano; Esposito, Dario

doi:10.1007/s10549-015-3619-5

Cited by 3 publications

(1 citation statement)

References 2 publications

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“…These high resolution microscopy images can be acquired at video rates by relaying light to and from the tissue using fibre-optic imaging bundles and a micro-lens, allowing a compact probe design without complex mechanical components [4]. Preliminary studies have shown potential applications in neurosurgery [5] for optimising resection, in head and neck surgery [6] for early detection and resection of squamous cell carcinomas, in breast surgery [7], [8] for distinguishing neoplastic from non-neoplastic cells, and for diagnostic purposes in gastrointestinal, colorectal, gastric, urinary tract, ovarian and lung cancer [9].…”

Section: Laser Ablation Fibrementioning

confidence: 99%

Intraoperative Robotic-Assisted Large-Area High-Speed Microscopic Imaging and Intervention

Γιαταγάνας

Hughes

Wisanuvej

et al. 2019

IEEE Trans. Biomed. Eng.

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Section: Laser Ablation Fibrementioning

confidence: 99%

Intraoperative Robotic-Assisted Large-Area High-Speed Microscopic Imaging and Intervention

Γιαταγάνας

Hughes

Wisanuvej

et al. 2019

IEEE Trans. Biomed. Eng.

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Towards an Optical Biopsy during Visceral Surgical Interventions

et al. 2020

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Background: Cancer will replace cardiovascular diseases as the most frequent cause of death. Therefore, the goals of cancer treatment are prevention strategies and early detection by cancer screening and ideal stage therapy. From an oncological point of view, complete tumor resection is a significant prognostic factor. Optical coherence tomography (OCT) and confocal laser microscopy (CLM) are two techniques that have the potential to complement intraoperative frozen section analysis as in vivo and real-time optical biopsies. Summary: In this review we present both procedures and review the progress of evaluation for intraoperative application in visceral surgery. For visceral surgery, there are promising studies evaluating OCT and CLM; however, application during routine visceral surgical interventions is still lacking. Key Message: OCT and CLM are not competing but complementary approaches of tissue analysis to intraoperative frozen section analysis. Although intraoperative application of OCT and CLM is at an early stage, they are two promising techniques of intraoperative in vivo and real-time tissue examination. Additionally, deep learning strategies provide a significant supplement for automated tissue detection.

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Endoscopic confocal laser-microscopy for the intraoperative nerve recognition: is it feasible?

Ellebrecht

Weihe

2021

Biomedical Engineering / Biomedizinische Technik

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Surgeons lose most of their tactile tissue information during minimal invasive surgery and need an additional tool of intraoperative tissue recognition. Confocal laser microscopy (CLM) is a well-established method of tissue investigation. The objective of this study was to analyze the feasibility and diagnostic accuracy of CLM nervous tissue recognition. Images taken with an endoscopic CLM system of sympathetic ganglions, nerve fibers and pleural tissue were characterized in terms of specific signal-patterns ex-vivo. No fluorescent dye was used. Diagnostic accuracy of tissue classification was evaluated by newly trained observers (sensitivity, specificity, PPV, NPV and interobserver variability). Although CLM images showed low CLM image contrast, assessment of nerve tissue was feasible without any fluorescent dye. Sensitivity and specificity ranged between 0.73 and 0.9 and 0.55–1.0, respectively. PPVs were 0.71–1.0 and the NPV range was between 0.58 and 0.86. The overall interobserver variability was 0.36. The eCLM enables to evaluate nervous tissue and to distinguish between nerve fibers, ganglions and pleural tissue based on backscattered light. However, the low image contrast and the heterogeneity in correct tissue diagnosis and a fair interobserver variability indicate the limit of CLM imaging without any fluorescent dye.

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Confocal laser endomicroscopy in breast surgery

Cited by 3 publications

References 2 publications

Intraoperative Robotic-Assisted Large-Area High-Speed Microscopic Imaging and Intervention

Intraoperative Robotic-Assisted Large-Area High-Speed Microscopic Imaging and Intervention

Towards an Optical Biopsy during Visceral Surgical Interventions

Endoscopic confocal laser-microscopy for the intraoperative nerve recognition: is it feasible?

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