Confirming <i>RGS4</i> as a susceptibility gene for schizophrenia

Morris, Derek W.; Rodgers, Alana; McGhee, Kevin A.; Schwaiger, Siobhan; Scully, Paul J.; Quinn, John F.; Meagher, David; Waddington, John L.; Gill, Michael; Corvin, Aiden

doi:10.1002/ajmg.b.20109

Cited by 129 publications

(91 citation statements)

References 13 publications

(16 reference statements)

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“…The whole RGS4 gene was in a large LD structure, which was also supported by previous studies. 30,31 Although all the polymorphisms tested were negative, this may not be sufficient to rule out the possibility of association of other risk polymorphisms, which locate out of the strong LD structure for each gene, considering the positive evidence in previous studies. Further investigation of other at-risk polymorphisms or haplotypes, particularly exhaustive analyses at each locus, is necessary.…”

Section: Discussionmentioning

confidence: 83%

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Association study of the G-protein signaling 4 (RGS4) and proline dehydrogenase (PRODH) genes with schizophrenia: a meta-analysis

2006

Eur J Hum Genet

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Schizophrenia is a devastating psychiatric disease that affects up to 1% of the population worldwide. Recent studies suggested that schizophrenia might result from the hypofunction of glutamatergic neurotransmission. Systematic positional, expression and functional studies have implicated the regulator of G-protein signaling 4 (RGS4) and proline dehydrogenase (PRODH) genes as promising and novel candidates for explaining schizophrenia. However, the findings of association studies tend to vary depending on the different populations on which they have been conducted. To reconcile this conflict of evidence, we combined all available population-based and family-based studies up to July 2005 involving eight polymorphisms. However, this meta-analysis did not find statistically significant evidence for association between the two glutamate-related genes and schizophrenia on the basis of either allelic or genotypic analysis. This may be the first systematic meta-analysis study based on RGS4 and PRODH.

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Section: Discussionmentioning

confidence: 83%

“…For RGS4, different susceptible alleles were detected, and the risk allele frequencies were in different directions in different populations (four studies 15,30,32 reported the G allele as the risk allele but two studies 15,31 found it had the protective effect). Several possible reasons may exist for the observed discrepancies.…”

Section: Discussionmentioning

confidence: 99%

Association study of the G-protein signaling 4 (RGS4) and proline dehydrogenase (PRODH) genes with schizophrenia: a meta-analysis

2006

Eur J Hum Genet

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“…The genetic association between RGS4 and schizophrenia was detected initially in three different populations by Chowdari et al (20), and confirmed in five subsequent replication studies (21)(22)(23)(24)(25). However, there have been four reports of failures to replicate an association of RGS4 and schizophrenia (26)(27)(28)(29).…”

Section: Introductionmentioning

confidence: 87%

Ethnic Stratification of the Association of RGS4 Variants with Antipsychotic Treatment Response in Schizophrenia

Campbell

Ebert

Skelly

et al. 2008

Biological Psychiatry

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Background-Genetic association studies, including a large meta-analysis, report association of Regulator of G Protein Signaling 4 (RGS4) with schizophrenia in the context of heterogeneity. The central role of RGS4 in regulating signaling via Gi/o coupled neurotransmitter receptors led us to hypothesize that there may be RGS4 genotypes predictive of specific disease phenotypes and antipsychotic treatment responses.

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“…7 Several studies confirmed this finding. [8][9][10] A similar approach to identify candidate genes may also be effective for bipolar disorder.…”

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confidence: 99%

Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia

et al. 2005

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We previously reported that expression level of LIM (ENH, PDLIM5) was significantly and commonly increased in the brains of patients with bipolar disorder, schizophrenia, and major depression. Expression of LIM was decreased in the lymphoblastoid cells derived from patients with bipolar disorders and schizophrenia. LIM protein reportedly plays an important role in linking protein kinase C with calcium channel. These findings suggested the role of LIM in the pathophysiology of bipolar disorder and schizophrenia. To further investigate the role of LIM in these mental disorders, we performed a replication study of gene expression analysis and performed genetic association studies. Upregulation of LIM was confirmed in the independent sample set obtained from Stanley Array Collection. No effect of sample pH or medication was observed. Genetic association study revealed the association of single nucleotide polymorphism (SNP)1 (rs10008257) with bipolar disorder. In an independent sample set, SNP2 (rs2433320) close to SNP1 was associated with bipolar disorder. In total samples, haplotype of these two SNPs was associated with bipolar disorder. No association was observed in case-control analysis and family-based association analysis in schizophrenia. These results suggest that SNPs in the upstream region of LIM may confer the genetic risk for bipolar disorder.

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Confirming RGS4 as a susceptibility gene for schizophrenia

Cited by 129 publications

References 13 publications

Association study of the G-protein signaling 4 (RGS4) and proline dehydrogenase (PRODH) genes with schizophrenia: a meta-analysis

Association study of the G-protein signaling 4 (RGS4) and proline dehydrogenase (PRODH) genes with schizophrenia: a meta-analysis

Ethnic Stratification of the Association of RGS4 Variants with Antipsychotic Treatment Response in Schizophrenia

Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia

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