Purpose
Confirmatory factor analysis (CFA) was used to test the hypothesis whether adipocytokines are associated with the risk factor cluster that characterizes the metabolic syndrome (MetS).
Methods
Data from 134 nondiabetic subjects were analyzed using CFA. Insulin sensitivity (SI) was quantified using intravenous glucose tolerance tests, visceral fat area by CT scan and fasting HDL, triglycerides, monocyte chemo-attractant protein-1 (MCP-1), serum amyloid A (SAA), tumor necrosis factor-α (TNF-α), adiponectin, resistin, leptin, interleukin-6 (IL-6), C-reactive protein (CRP) and plasminogen activator inhibitor-1 (PAI-1) were measured.
Results
The basic model representing the MetS included six indicators comprising obesity, SI, lipids and hypertension, and demonstrated excellent goodness-of-fit. Using multivariate analysis, MCP-1, SAA and TNF-α were not independently associated with any of the MetS variables. Adiponectin, resistin, leptin, CRP and IL-6 were associated with at least one of the risk factors, but when added to the basic model decreased all goodness-of-fit parameters. PAI-1 was associated with all cardiometabolic factors and improved goodness-of-fit compared to the basic model.
Conclusions
Addition of PAI-1 increased the CFA model goodness-of-fit compared to the basic model, suggesting that this protein may represent an added feature of the MetS.