Confirmation of spectinomycin in milk using ion-pair solid-phase extraction and liquid chromatography–electrospray ion trap mass spectrometry

Quantitative measurement of plasma free metanephrines by ion-pairing solid phase extraction and liquid chromatography–tandem mass spectrometry with porous graphitic carbon column

“…Ion-paring (IP)-SPE has been used to purify a wide range of polar compounds including sugars, amino acids, phenols, biogenic amines, nucleosides/nucleotides, and triacylglycerides [17,18]. Ionparing reagents have both polar and non-polar moieties.…”

Determination of spectinomycin hydrochloride and its related substances by HPLC–ELSD and HPLC–MSn

“…This principle is applied in the search of impurities in pharmaceutical products. At the same time, the structural information of impurities in pharmaceutical products can be obtained by HPLC-MS n [6][7][8][9][10].…”

High-performance liquid chromatographic determination of vertilmicin in rat plasma using sensitive fluorometric derivatization

“…1). The analysis of aminoglycosides are usually performed using pre-column [2][3][4][5][6][7][8] and post-column derivatization [9] methods, or other detections such as evaporative light scattering detection [10], pulsed electrochemical detection [11][12][13] and mass spectrometry [12,14,15]. Zhou et al [16] had reported an analytical method for veritlmicin in plasma and 1-fluoro-2,4-dinitrobenzene was used for derivatization.…”